F-box/WD repeat-containing protein 7 is a protein that in humans is encoded by the FBXW7 gene. [5][6][7] This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box.

Dec 25, 2024 · FBXW7 (F-Box And WD Repeat Domain Containing 7) is a Protein Coding gene. Diseases associated with FBXW7 include Developmental Delay, Hypotonia, And Impaired Language and Colorectal Cancer. Among its related pathways are Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants and Class I MHC mediated antigen processing and …

Aug 7, 2018 · FBXW7 is a critical tumor suppressor and one of the most commonly deregulated ubiquitin-proteasome system proteins in human cancer. FBXW7 controls proteasome-mediated degradation of oncoproteins such as cyclin E, c-Myc, Mcl-1, mTOR, Jun, Notch and AURKA.

FBXW7 (F-Box and WD Repeat Domain Containing 7) (also referred to as FBW7 or hCDC4) is a component of the Skp1-Cdc53 / Cullin-F-box-protein complex (SCF/β-TrCP). As a member of the F-box protein family, FBXW7 serves a role in ...

The FBXW7 (F-box with 7 tandem WD40) protein encoded by the gene FBXW7 is one of the crucial components of ubiquitin ligase called Skp1-Cullin1-F-box (SCF) complex that aids in the degradation of many oncoproteins via the ubiquitin-proteasome system …

Feb 9, 2025 · FBXW7 polymorphism asserts susceptibility to colorectal cancer. Fbxw7 suppresses carcinogenesis and stemness in triple-negative breast cancer through CHD4 degradation and Wnt/beta-catenin pathway inhibition. FBXW7 inhibits the progression of ESCC by directly inhibiting the stemness of tumor cells.

Sep 2, 2023 · Low levels of FBXW7 cause abnormal stability of pertinent substrates, mutations and/or deletions in the FBXW7 gene have been reported to correlate with breast cancer malignant progression and chemoresistance.