
FBXW7 - Wikipedia
F-box/WD repeat-containing protein 7 is a protein that in humans is encoded by the FBXW7 gene. [5][6][7] This gene encodes a member of the F-box protein family which is characterized by an …
FBXW7 Gene - GeneCards | FBXW7 Protein | FBXW7 Antibody
2024年12月25日 · FBXW7 (F-Box And WD Repeat Domain Containing 7) is a Protein Coding gene. Diseases associated with FBXW7 include Developmental Delay, Hypotonia, And …
Clinical significance of FBXW7 loss of function in human cancers
FBXW7 (F-Box and WD Repeat Domain Containing 7) (also referred to as FBW7 or hCDC4) is a component of the Skp1-Cdc53 / Cullin-F-box-protein complex (SCF/β-TrCP). As a member of …
FBXW7: a critical tumor suppressor of human cancers - PubMed
2018年8月7日 · FBXW7 is a critical tumor suppressor and one of the most commonly deregulated ubiquitin-proteasome system proteins in human cancer. FBXW7 controls proteasome …
FBXW7: a critical tumor suppressor of human cancers
2018年8月7日 · FBXW7 is a critical tumor suppressor and one of the most commonly deregulated ubiquitin-proteasome system proteins in human cancer. FBXW7 controls proteasome …
FBXW7 in Cancer: What Has Been Unraveled Thus Far? - PMC
The FBXW7 (F-box with 7 tandem WD40) protein encoded by the gene FBXW7 is one of the crucial components of ubiquitin ligase called Skp1-Cullin1-F-box (SCF) complex that aids in …
FBXW7 tumor suppressor regulation by dualspecificity tyrosine
2023年3月18日 · FBXW7 is a main tumor suppressor due to its ability to control proteasome-mediated degradation of several oncoproteins such as c-Jun, c-Myc, Cyclin E1, mTOR, and …
FBXW7 attenuates tumor drug resistance and enhances the …
Through degradation of its substrates, FBXW7 plays a pivotal role in drug resistance in tumor cells and shows the potential to rescue the sensitivity of cancer cells to drug treatment. This …
FBXW7 and the Hallmarks of Cancer: Underlying Mechanisms and ...
2022年4月18日 · In this review, we mainly elaborate on seven hallmarks of cancer influenced by FBXW7, including maintaining growth signals, resisting cell death, inducing angiogenesis, …
FBXW7 F-box and WD repeat domain containing 7 [ (human)]
2025年2月9日 · FBXW7 polymorphism asserts susceptibility to colorectal cancer. Fbxw7 suppresses carcinogenesis and stemness in triple-negative breast cancer through CHD4 …