Dec 25, 2024 · FBXO44 (F-Box Protein 44) is a Protein Coding gene. Diseases associated with FBXO44 include Congenital Disorder Of Deglycosylation 1. Among its related pathways are Class I MHC mediated antigen processing and presentation and Metabolism of proteins. An important paralog of this gene is FBXO6.

Jan 21, 2021 · FBXO44 expression inversely correlated with replication stress, antiviral pathways, IFN signaling, and cytotoxic T cell infiltration in human cancers, while a FBXO44-immune gene signature correlated with improved immunotherapy response in cancer patients.

FBXO44/SUV39H1 inhibition reactivated REs, leading to DNA replication stress and stimulation of MAVS/STING antiviral pathways and interferon (IFN) signaling in cancer cells to promote decreased tumorigenicity, increased immunogenicity, and enhanced immunotherapy response.

Nov 30, 2012 · Small interfering RNA screening that targets all human F-box proteins uncovered FBXO44 as an important protein that influences BRCA1 protein level. The Skp1-Cul1-F-box-protein44 (SCF(FBXO44)) complex ubiquitinates full-length BRCA1 in vitro.

Dec 3, 2024 · FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells. Shen JZ, Qiu Z, Wu Q, Finlay D, Garcia G, Sun D, Rantala J, Barshop W, Hope JL, Gimple RC, Sangfelt O, Bradley LM, Wohlschlegel J, Rich JN, Spruck CShen JZ, et al. Cell, 2021 Jan 21. PMID 33357448.

Using a genomic siRNA screening approach, we identified a novel E3 ligase complex containing cullin 4B (CUL4B), DNA damage binding protein 1 (DDB1) and F-box protein 44 (FBXO44) that mediates RGS2 protein degradation.

FBXO44/SUV39H1 targeting activates REs that elicit DNA replication stress and viral mimicry in cancer cells, leading to tumor growth arrest and enhanced immunotherapy response.

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Nov 11, 2024 · Here, we report an aging-associated mechanism in cardiomyocytes in which Fbxo44 disrupts mitochondrial calcium homeostasis by promoting phosphorylation of the calcium release channel protein RyR2. Hypothesis: Fbxo44 regulates cardiac aging through the RyR2-related pathway.

View mouse Fbxo44 Chr4:148237256-148244663 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression