The transporter for long-chain fatty acids in the apical side of the mature enterocyte is fatty acid transporter protein 4 (FATP4). In the human, there is a family of six homologous transporters (FATP1 through FATP6) and they occur variously in all the fatty acid utilizing tissues in the body.

2019年9月13日 · Fatty acid transport protein 4 (FATP4) is an acyl-CoA synthetase that is required for normal permeability barrier in mammalian skin. FATP4 (SLC27A4) mutations cause ichthyosis prematurity...

2022年6月30日 · The widely distributed FATP4 is not a direct FA transporter but plays a predominant function as an ACS. FATP4 deficiency causes ichthyosis premature syndrome in mice and humans associated with suppression of polar lipids but an increase in neutral lipids including triglycerides (TGs).

2004年7月5日 · SLC27A4/FATP4-mediated fatty acid uptake is associated to paramaters related to insulin resistance, which is associated with disturbed fatty acid metabolism and homeostasis, such as obesity. SLC27A4/FATP4 expression is positively correlated with acquired obesity.

In vivo, FAT/CD36 and FATP4 are the most effective fatty acid transporters, whereas FABPpm and FAT/CD36 are key for stimulating fatty acid oxidation. Uptake of long chain fatty acids across the plasma membrane had long been considered to occur via passive diffusion.

2001年5月30日 · FATP4 (SLC27A4) is a member of the fatty acid transport protein (FATP) family, a group of evolutionarily conserved proteins that are involved in cellular uptake and metabolism of long and very long chain fatty acids. We cloned and …

2021年6月15日 · FATP4 is the primary intestinal fatty acid transport protein and is thought to play a major role in dietary fatty acid uptake. It has therefore been viewed as a target to prevent or reverse obesity. However, its function in vivo had not been determined.

2001年5月30日 · FATP4 (SLC27A4) is a member of the fatty acid transport protein (FATP) family, a group of evolutionarily conserved proteins that are involved in cellular uptake and metabolism of long and very long chain fatty acids. We cloned and …

FATP4 is localized mainly at the endoplasmic reticulum (ER) and partially localized to peroxisomes [55, 60]. It plays a role in FA transport via ACS-activated vectorial acylation [48, 55,60–63], that the depleted intracellular FA concentrations indirectly trigger an FA uptake.

Fatty acid transport protein (FATP) 4 is one of a family of six FATPs that facilitate long- and very long-chain fatty acid uptake. Mice lacking FATP4 are born with tight, thick skin and a defective epidermal barrier; they die neonatally due to dehydration and restricted movements.

2012年9月14日 · Here, we used a gain-of-function approach and established FATP1, ACSVL4/FATP4 and ACSL1 stably expressing 3T3-L1 adipocytes by retroviral transduction. All overexpressing cell lines showed increased acyl-CoA synthetase activity and fatty acid uptake.

Fatp4 (-/-);Ivl-Fatp4 (tg/+) mice and wild-type littermates displayed indistinguishable food consumption, growth, and weight gain on either low or high fat (Western) diets, with no differences in intestinal triglyceride (TG) absorption or fecal fat losses.

FA transport protein 4 (FATP4), one member of a multigene family of FA transporters, was proposed as a major FA transporter in intestinal lipid absorption. Due to the fact that Fatp4−/− mice die because of a perinatal skin defect, we rescued the ...

Fatty acid transport protein 4 (FATP4) is an integral membrane protein expressed in the plasma and internal membranes of the small intestine and adipocyte as well as in the brain, kidney, liver, skin, and heart.

2001年5月30日 · FATP4 (SLC27A4) is a member of the fatty acid transport protein (FATP) family, a group of evolutionarily conserved proteins that are involved in cellular uptake and metabolism of long and very long chain fatty acids. We cloned and …

Fatty acid transport protein 4 (FATP4) is a fatty acyl-CoA synthetase that preferentially activates very long chain fatty acid substrates, such as C24:0, to their CoA derivatives.

Fatty acid-binding protein 4 (FABP4), also known as adipocyte FABP (A-FABP) or aP2, is mainly expressed in adipocytes and macrophages and plays an important role in the development of insulin resistance and atherosclerosis in relation to metaflammation.

2007年7月13日 · Fatty acid transport protein 4 (FATP4) is a fatty acyl-CoA synthetase that preferentially activates very long chain fatty acid substrates, such as C24:0, to their CoA derivatives.

2025年3月3日 · Another complex consisting of PLIN5 and FATP4 79 was shown to enhance LD-mitochondria contact and increase fatty acid oxidation, however, direct evidence of fatty acid transfer by this complex ...

2022年6月1日 · FATP4 is localized mainly at the endoplasmic reticulum (ER) and partially localized to peroxisomes [55,60]. It plays a role in FA transport via ACS-activated vectorial acylation [48,55,60–63], that the depleted intracellular FA concentrations indirectly trigger an …