
FANCJ is a structure-specific DNA helicase associated with the ...
2008年12月26日 · Here we demonstrate that one component of this pathway, FANCJ, is a structure-specific DNA helicase that dissociates guanine quadruplex DNA (G4 DNA) in vitro. Moreover, in contrast with previously identified G4 DNA helicases, such as the Bloom's helicase (BLM), FANCJ unwinds G4 substrates with 5'-3' polarity.
Molecular and cellular functions of the FANCJ DNA helicase …
FANCJ is linked to cancer suppression and DNA double strand break repair through its direct interaction with the hereditary breast cancer associated gene product, BRCA1. FANCJ also operates in the FA pathway of interstrand cross-link repair and …
FANCJ Helicase Operates in the Fanconi Anemia DNA Repair …
Fanconi anemia (FA) is an autosomal recessive disorder characterized by multiple congenital anomalies, progressive bone marrow failure, and high cancer risk. Cells from FA patients exhibit spontaneous chromosomal instability and hypersensitivity to DNA …
FANCJ promotes PARP1 activity during DNA replication that is
2024年3月23日 · Indicating sequestered and trapped PARP1 are distinct, FANCJ loss increases PARPi resistance in cells susceptible to PARP1 trapping.
FANCJ Is a Structure-specific DNA Helicase Associated with the ...
Here we demonstrate that one component of this pathway, FANCJ, is a structure-specific DNA helicase that dissociates guanine quadruplex DNA (G4 DNA) in vitro. Moreover, in contrast with previously identified G4 DNA helicases, such as the Bloom's helicase (BLM), FANCJ unwinds G4 substrates with 5′–3′ polarity.
BRIP1 Gene - GeneCards | FANCJ Protein | FANCJ Antibody
2024年12月24日 · BRIP1 (BRCA1 Interacting Helicase 1) is a Protein Coding gene. Diseases associated with BRIP1 include Fanconi Anemia, Complementation Group J and Breast Cancer. Among its related pathways are Homologous DNA Pairing and Strand Exchange and Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA).
FANCJ DNA helicase is recruited to the replisome by AND-1 to …
2024年1月2日 · FANCJ/BRIP1, a DNA helicase counteracting replication stress, is recruited to the DNA replication machinery by directly binding to AND-1. Disruption of the FANCJ/AND-1 interaction causes enhanced DNA damage, replication fork stalling and asymmetry in either unperturbed or stressful conditions.
Molecular and cellular functions of the FANCJ DNA helicase
2014年10月21日 · FANCJ resolves G-quadruplex (G4) DNA structures that are known to affect cellular replication and transcription, and potentially play a role in the preservation and functionality of chromosomal structures such as telomeres.
The FANCJ helicase unfolds DNA-protein crosslinks to promote …
2023年1月5日 · FANCJ binds ssDNA downstream of the DPC and uses its ATPase activity to unfold the protein adduct, which exposes the underlying DNA and enables cleavage of the adduct. FANCJ-dependent DPC unfolding is also essential for translesion DNA synthesis past DPCs that cannot be degraded.
FANCJ helicase controls the balance between short- and long …
2017年9月6日 · The FANCJ DNA helicase is linked to hereditary breast and ovarian cancers as well as bone marrow failure disorder Fanconi anemia (FA). Although FANCJ has been implicated in the repair of DNA double-strand breaks (DSBs) by homologous recombination (HR), the molecular mechanism underlying the tumor suppressor functions of FANCJ remains obscure.