
FANCJ is a structure-specific DNA helicase associated with the ...
2008年12月26日 · Here we demonstrate that one component of this pathway, FANCJ, is a structure-specific DNA helicase that dissociates guanine quadruplex DNA (G4 DNA) in vitro. …
Molecular and cellular functions of the FANCJ DNA helicase …
FANCJ is linked to cancer suppression and DNA double strand break repair through its direct interaction with the hereditary breast cancer associated gene product, BRCA1. FANCJ also …
FANCJ Helicase Operates in the Fanconi Anemia DNA Repair …
Fanconi anemia (FA) is an autosomal recessive disorder characterized by multiple congenital anomalies, progressive bone marrow failure, and high cancer risk. Cells from FA patients …
FANCJ promotes PARP1 activity during DNA replication that is
2024年3月23日 · Indicating sequestered and trapped PARP1 are distinct, FANCJ loss increases PARPi resistance in cells susceptible to PARP1 trapping.
FANCJ Is a Structure-specific DNA Helicase Associated with the ...
Here we demonstrate that one component of this pathway, FANCJ, is a structure-specific DNA helicase that dissociates guanine quadruplex DNA (G4 DNA) in vitro. Moreover, in contrast …
BRIP1 Gene - GeneCards | FANCJ Protein | FANCJ Antibody
2024年12月24日 · BRIP1 (BRCA1 Interacting Helicase 1) is a Protein Coding gene. Diseases associated with BRIP1 include Fanconi Anemia, Complementation Group J and Breast …
FANCJ DNA helicase is recruited to the replisome by AND-1 to …
2024年1月2日 · FANCJ/BRIP1, a DNA helicase counteracting replication stress, is recruited to the DNA replication machinery by directly binding to AND-1. Disruption of the FANCJ/AND-1 …
Molecular and cellular functions of the FANCJ DNA helicase
2014年10月21日 · FANCJ resolves G-quadruplex (G4) DNA structures that are known to affect cellular replication and transcription, and potentially play a role in the preservation and …
The FANCJ helicase unfolds DNA-protein crosslinks to promote …
2023年1月5日 · FANCJ binds ssDNA downstream of the DPC and uses its ATPase activity to unfold the protein adduct, which exposes the underlying DNA and enables cleavage of the …
FANCJ helicase controls the balance between short- and long …
2017年9月6日 · The FANCJ DNA helicase is linked to hereditary breast and ovarian cancers as well as bone marrow failure disorder Fanconi anemia (FA). Although FANCJ has been …