Dec 15, 2016 · FR104 is a monovalent pegylated Fab' Ab, antagonist of CD28, under development for treatment of transplant rejection and autoimmune diseases. In contrast to CD80/86 antagonists (CTLA4-Ig), FR104 selectively blunts CD28 costimulation while sparing CTLA-4 and PD-L1 coinhibitory signals.

Here, we evaluate FR104, a novel antagonist pegylated anti-CD28 Fab' antibody fragment, in nonhuman primate renal allotransplantation. FR104, in association with low doses of tacrolimus or with rapamycin in a steroid-free therapy, prevents acute rejection and alloantibody development and prolongs allograft survival.

Here, we describe FR104, a novel humanized pegylated anti-CD28 Fab' antibody fragment presenting a long elimination half-life in monkeys. In vitro, FR104 failed to induce human T cell proliferation and cytokines secretion, even in the presence of anti-CD3 antibodies or when cross-linked with secondary antibodies.

The FR104 Diode is a fast switching diode, with a continuous reverse voltage rating of 400V and is suitable for forward currents of up to 1A, the reverse recovery time is 150ns. The FR104 diode is ideal for use in linear and switched voltage converter circuits.

FR104/VEL-101 is a pegylated monoclonal antibody fragment that binds to and blocks CD28-mediated effector- T cell co-stimulation, without blocking CTLA-4, an important protein receptor found on T cells that acts as a

VEL-101, a novel investigational immunosuppressant formerly known as FR104, is a monoclonal antibody fragment that inhibits costimulation via direct CD28 blockade. 1 VEL-101 will be developed as a subcutaneous, at-home self-administration medication that may eliminate many of the toxicities seen with current standard of care immunosuppression. 2

FR104/VEL-101. a monoclonal antibody fragment and CD28 antagonist, selectively blunts CD28 co-stimulation while sparing the CTLA-4 co-inhibitory signal. The net effect of CD28 antagonism is down regulating effector T-cells while promoting T-Reg activity.

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Jul 16, 2020 · Recently, FR104, a novel monoclonal antibody fragment that antagonizes CD28, was developed. This CD28 antagonist selectively and efficiently prevents CD28 interaction with B7 molecules, while sparing the CTLA-4 co-inhibitory signal.

FR104 is a new generation product, a monoclonal antibody fragment and antagonist of CD28, a key receptor in effector T lymphocytes, with preclinical proof of concept demonstrated in autoimmune diseases and transplantation.