Forkhead box protein P2 (FOXP2) is a protein that, in humans, is encoded by the FOXP2 gene. FOXP2 is a member of the forkhead box family of transcription factors, proteins that regulate gene expression by binding to DNA. It is expressed in the brain, heart, lungs and digestive system. [5] [6]

The FOXP2 gene provides instructions for making a protein that acts as a transcription factor, which means that it controls the activity of other genes. It attaches (binds) to the DNA of these genes at a region of the protein known as a forkhead domain.

2024年12月25日 · FOXP2 (Forkhead Box P2) is a Protein Coding gene. Diseases associated with FOXP2 include Isolated Childhood Apraxia Of Speech and Language Disorder. Among its related pathways are Pathways affected in adenoid cystic carcinoma and Wnt / Hedgehog / Notch.

2025年2月8日 · FOXP2 suppresses the proliferation, invasion, and aerobic glycolysis of hepatocellular carcinoma cells by regulating the KDM5A/FBP1 axis. LncRNA CERS6-AS1, sponging miR-6838-5p, promotes proliferation and invasion in cervical carcinoma cells by upregulating FOXP2.

2005年2月1日 · FOXP2 encodes a transcription factor that is expressed in the brain, lungs, heart and gut. In the brain, it is widely expressed in sensory, limbic and motor structures. The effects of a mutation...

2021年7月14日 · Here, we discuss what we have learned about the regulation of FOXP2, its downstream effectors, and its modes of action as a transcription factor in brain development and function, providing an integrated overview of what is currently known about the …

The forkhead box P2 gene, designated FOXP2, is the first gene implicated in a speech and language disorder. Since its discovery, many studies have been carried out in an attempt to explain the mechanism by which it influences these ...

2019年1月21日 · FOXP2 mutations cause a speech and language disorder, raising interest in potential roles of this gene in human evolution. A new study re-evaluates genomic variation at the human FOXP2 locus but finds no evidence of recent adaptive evolution.

2002年8月14日 · Here we show that human FOXP2 contains changes in amino-acid coding and a pattern of nucleotide polymorphism, which strongly suggest that this gene has been the target of selection during recent...

2025年2月8日 · Title: Novel FOXP2 variant associated with speech and language dysfunction in a Chinese family and literature review. FOXP2 suppresses the proliferation, invasion, and aerobic glycolysis of hepatocellular carcinoma cells by regulating the KDM5A/FBP1 axis.

2019年1月21日 · FOXP2 mutations cause a speech and language disorder, raising interest in potential roles of this gene in human evolution. A new study re-evaluates genomic variation at the human FOXP2 locus but finds no evidence of recent adaptive evolution.

2009年5月29日 · Now, Enard, Paabo and their colleagues shed new light on the role of the FOXP2 gene on the evolution of human language and cognition (Enard et al., 2009). They report, in this issue, the results of introducing into mice the human version of the Foxp2 gene.

FOXP2, initially identified for its role in human speech, contains two nonsynonymous substitutions derived in the human lineage. Evidence for a recent selective sweep in Homo sapiens, however, is at odds with the presence of these substitutions in archaic hominins.

2024年5月25日 · Here we report that the parabrachial respiratory neurons express FoxP2 and are required for respiratory responses to elevated CO2.

The forkhead box P2 gene, designated FOXP2, is the first gene implicated in a speech and language disorder. Since its discovery, many studies have been carried out in an attempt to explain the mechanism by which it influences these characteristically human traits.

2013年2月2日 · The FOXP2 gene is central to acquisition of speech and language in humans and vocal production in birds and mammals. Rodents communicate via ultrasonic vocalizations (USVs) and newborn pups emit distress USVs when …

FOXP2 is a transcription factor and modulates DNA transcription at numerous loci throughout the genome, underscoring the importance of transcriptional regulation in dyslexia and other neurobehavioral disorders. Interestingly, one of its gene targets is …

2011年7月7日 · Most notably, we found that Foxp2 directly and indirectly regulates networks of genes that alter the length and branching of neuronal projections, an important route for modulating the wiring of neural connections in the developing brain.

2009年3月23日 · Rare mutations of the FOXP2 transcription factor gene cause a monogenic syndrome characterized by impaired speech development and linguistic deficits. Recent genomic investigations indicate that its downstream neural targets make broader impacts on common language impairments, bridging clinically distinct disorders.

2018年1月23日 · We manipulated FoxP2 isoforms in Area X, a song-specific region of the avian striatopallidum analogous to human anterior striatum, during a critical period for song development. We delineate, for the first time, unique contributions of each isoform to …