Forkhead box C1, also known as FOXC1, is a protein which in humans is encoded by the FOXC1 gene. [5][6][7] This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding fork head domain.

Dec 25, 2024 · FOXC1 (Forkhead Box C1) is a Protein Coding gene. Diseases associated with FOXC1 include Anterior Segment Dysgenesis 3 and Axenfeld-Rieger Syndrome, Type 3. Among its related pathways are Kidney development and Gastrulation.

Mar 13, 2017 · FOXC1 is involved in the development of many organs during embryogenesis, such as brain, eye, heart and bone. FOXC1 exerts its function in many aspects of cancer progression including...

Oct 9, 2023 · foxc1在胚胎、生理及病理过程中的作用. foxc1信使rna (mrna)可在多种胚胎组织中检测到，包括原肠形成早期的近轴中胚层、排卵后8.5天的体前中胚层、眼周间质、角膜、中肾小管和周围的间质、内皮细胞。这些广泛的表达模式表明foxc1在早期胚胎发育中的必要性。

The FOXC1 gene provides instructions for making a protein that attaches (binds) to specific regions of DNA and regulates the activity of other genes. Learn about this gene and related health conditions.

Foxc1 敲低损害了 FGF2 介导的 NMuMG 细胞的三维迁移能力，该能力被 FGFR1 的表达所拯救。 此外，在迁移性间充质 MDA-MB-231 乳腺癌细胞中也观察到 FOXC1 和 FGFR1 的表达升高。

Nov 23, 2017 · FOXC1 regulates tumor-associated genes and is regulated by multiple pathways that control its mRNA expression and protein activity. Aberrant FOXC1 expression is involved in diverse tumorigenic processes, such as abnormal cell proliferation, cancer stem cell maintenance, cancer migration, and angiogenesis.

Jul 13, 2017 · FOXC1 is highly and specifically expressed in BLBC as opposed to other breast cancer subtypes. Its functions in breast cancer have been extensively explored. This review will summarize current knowledge on the function and regulation of FOXC1 in tumor development and progression with a focus on BLBC, as well as the implications of these new ...

FOXC1可以通过多种信号通路调节癌干细胞(cancer stem cells,CSCs)的生物学特性,通过介导细胞周期蛋白D1、c-Myc和NF-κB的表达,增加CSCs的增殖;与HOXA/B信号通路协同,促进肿瘤的发生和进展;通过上调WNT信号的转录介质β-联蛋白或激活非典型Hedgehog信号增强CSCs活性;通过上 …

Jun 27, 2024 · 叉头框转录因子C1（FOXC1） 是FOX家族成员中的一种转录因子，在多种生物过程中发挥重要作用,包括细胞增殖、分化、凋亡、迁移、侵袭、新陈代谢及癌变。 大量的证据表明,FOXC1异常表达与多种恶性肿瘤发生、发展相关,例如乳腺癌、肝癌和胃癌等。 FOXC1在TNBC中的表达（约77％）显著高于Lumina A型（约5％），Lumina B型（约8％）和HER2阳性型（约26％）乳腺癌。 FOXC1是基底样型乳腺癌（BLBC）的特异性诊断标志物. FOXC1在识 …