Forkhead box C1, also known as FOXC1, is a protein which in humans is encoded by the FOXC1 gene. [5][6][7] This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding fork head domain.

FOXC1 is involved in the development of many organs during embryogenesis, such as brain, eye, heart and bone. FOXC1 exerts its function in many aspects of cancer progression including migration, invasion, and cancer stem cells.

2017年3月13日 · Most recently, a large body of literature has shown that FOXC1 plays a critical role in tumor development and metastasis. Clinical studies have demonstrated that elevated FOXC1 expression is...

2024年12月25日 · FOXC1 (Forkhead Box C1) is a Protein Coding gene. Diseases associated with FOXC1 include Anterior Segment Dysgenesis 3 and Axenfeld-Rieger Syndrome, Type 3. Among its related pathways are Kidney development and Gastrulation.

The FOXC1 gene provides instructions for making a protein that attaches (binds) to specific regions of DNA and regulates the activity of other genes. Learn about this gene and related health conditions.

FOXC1, which is also known as Mf1, Fkh-1 or FREAC3 , is a single exon gene located at 6p25 encoding a 533 aa protein that localizes to the nucleus, where it can bind to the DNA and regulate gene expression .

Forkhead box C1 (FOXC1) is an essential member of the forkhead box transcription factors and has been highlighted as an important transcriptional regulator of crucial proteins associated with a wide variety of carcinomas.

2017年7月13日 · The Forkhead box C1 (FOXC1) transcription factor is involved in normal embryonic development and regulates the development and function of many organs. Most recently, a large body of literature has shown that FOXC1 plays a critical role in tumor development and metastasis.

2022年8月1日 · FOXC1 expression was evaluated with IHC in a large cohort of 2443 patients with breast cancer. Receiver operating characteristic (ROC) curves were used to assess the diagnostic ability of FOXC1 expression to predict the triple-negative …

2024年2月27日 · Substantial evidence attests to the pivotal role of cancer stem cells (CSC) in both tumorigenesis and drug resistance. A member of the forkhead box (FOX) family, FOXC1, assumes significance in...