FK506-Binding Proteins and Their Diverse Functions - PMC
FK506 binding proteins (FKBPs) are a family of highly conserved proteins in eukaryotes. The prototype of this protein family, FKBP12, is the binding partner for immunosuppressive drugs …
FKBP Ligands—Where We Are and Where to Go? - PMC
Nov 18, 2021 · FK506-binding proteins (FKBPs) belong to the immunophilin family. Like other immunophilins many FKBPs possess a cis-trans peptidyl-prolyl isomerase (PPIase) activity. In …
FKBP family proteins: immunophilins with versatile biological …
FKBP family proteins play important functional roles in the T-cell activation, when complexed with their ligands. The roles of immunophilins in protein transportation and apoptosis through their …
Comparative analysis of FKBP family protein: evaluation, structure, …
Since FK506-binding proteins (FKBP) were first identified, much progress has been made in understanding the mechanisms involved in regulating the immunological process, steroid …
FKBP Ligands-Where We Are and Where to Go? - PubMed
Dec 5, 2018 · High-affinity ligands with selectivity between close homologs are scarce. This review will give an overview of the most prominent ligands developed for FKBPs and highlight …
FK506 binding proteins and inflammation related signalling ... - PubMed
FK506 binding (FKBP) proteins are part of the highly conserved immunophilin family and its members have fundamental roles in the regulation of signalling pathways involved in …
FKBP4 Gene - GeneCards | FKBP4 Protein | FKBP4 Antibody
Dec 25, 2024 · FKBP4 (FKBP Prolyl Isomerase 4) is a Protein Coding gene. Diseases associated with FKBP4 include Hypospadias and Ocular Hypertension. Among its related pathways are …
FKBP (FK506 Binding Protein) - SpringerLink
Jan 1, 2018 · FKBP (FK506 Binding Protein), Table 1 FKBP classification with synonyms of gene and protein. In the 1970s, after a decade from the purification of cyclosporine, a selective …
FKBP52功能及与疾病联系的研究进展 - pku.edu.cn
FKBP52为FK506结合蛋白...
FKBP family proteins as promising new biomarkers for cancer
Aug 1, 2011 · FKBPs participate in cancer cellular processes. FKBPs are implicated in cell growth and survival and apoptotic signaling pathways. FKBP51 provide a relevant tissue marker of …
FKBP10 Gene - GeneCards | FKB10 Protein | FKB10 Antibody
Dec 25, 2024 · FKBP10 (FKBP Prolyl Isomerase 10) is a Protein Coding gene. Diseases associated with FKBP10 include Bruck Syndrome 1 and Osteogenesis Imperfecta, Type Xi. …
Different Effects of Tacrolimus on Innate and Adaptive Immune …
Nov 2, 2015 · FK506 binds to a different immunophilin than CsA, called FK506-binding protein (FKBP) 12 13. Differences between CsA and FK506 with regard to adverse effects, safety and …
FK506-Binding Proteins and Their Diverse Functions - PubMed
FK506 binding proteins (FKBPs) are a family of highly conserved proteins in eukaryotes. The prototype of this protein family, FKBP12, is the binding partner for immunosuppressive drugs …
A subpopulation of CD146+ macrophages enhances
In this study, we identified a subpopulation of CD146 + TAMs that exerted antitumor activity in both human samples and animal models. CD146 expression in TAMs was negatively …
Regulation of pericyte metabolic reprogramming restricts the AKI …
Methods: Unilateral ischemia/reperfusion-induced AKI to CKD mouse model and TGF-β-treated pericyte-like cells were used to detect the levels of fatty acid oxidation (FAO) and glycolysis, …
FKBP Ligands—Where We Are and Where to Go? - Frontiers
Dec 5, 2018 · FK506-binding proteins (FKBPs) belong to the immunophilin family. Like other immunophilins many FKBPs possess a cis-trans peptidyl-prolyl isomerase (PPIase) activity. In …
Discovery of Potent Inhibitors against P-Glycoprotein-Mediated ...
In this article, a variety of SIS3 derivatives were designed and synthesized to discover potential inhibitors against P-glycoprotein-mediated multidrug resistance aided by late-stage …
FKBP family proteins as promising new biomarkers for cancer
FK506-binding proteins (FKBPs) belong to the immunophilin family and bind immunosuppressive drugs, such as FK506 and rapamycin.
Tracing Immunological Interaction in Trimethylamine N-Oxide …
Here, this work develops a strategy using novel trimethylamine N-oxide (TMAO)-derived zwitterionic hydrogel to promote diabetic wound healing, and explore the multi-cellular …
Enhanced liquidity of p62 droplets mediated by Smurf1 links Nrf2 ...
Results: In this study, we showed that E3 Ligase Smurf1 enhanced Nrf2 activation and promoted Autophagy by increasing p62 phase separation capability. Specifically, the Smurf1/ p62 …