FK506 binding proteins (FKBPs) are a family of highly conserved proteins in eukaryotes. The prototype of this protein family, FKBP12, is the binding partner for immunosuppressive drugs FK506 and rapamycin. FKBP12 functions as a cis/trans peptidyl prolyl isomerase (PPIase) that catalyzes interconversion between prolyl cis/trans conformations.

2021年11月18日 · FK506-binding proteins (FKBPs) belong to the immunophilin family. Like other immunophilins many FKBPs possess a cis-trans peptidyl-prolyl isomerase (PPIase) activity. In addition, they can act as a co-receptor for the natural products FK506 and Rapamycin.

Since FK506-binding proteins (FKBP) were first identified, much progress has been made in understanding the mechanisms involved in regulating the immunological process, steroid signaling, and the resulting roles they play in physiological processes.

2018年12月5日 · FK506-binding proteins (FKBPs) belong to the immunophilin family. Like other immunophilins many FKBPs possess a cis-trans peptidyl-prolyl isomerase (PPIase) activity. In addition, they can act as a co-receptor for the natural products FK506 and Rapamycin.

FK506-binding proteins (FKBPs) belong to the immunophilin family and bind immunosuppressive drugs, such as FK506 and rapamycin.

2011年8月1日 · FKBPs participate in cancer cellular processes. FKBPs are implicated in cell growth and survival and apoptotic signaling pathways. FKBP51 provide a relevant tissue marker of chemo-sensitivities and radio-sensitivities. FKBP52 autoantibodies are promising diagnostic cancer biomarkers.

FK506 binding (FKBP) proteins are part of the highly conserved immunophilin family and its members have fundamental roles in the regulation of signalling pathways involved in inflammation, adaptive immune responses, cancer and developmental biology.

2018年1月1日 · FKBP (FK506 Binding Protein), Table 1 FKBP classification with synonyms of gene and protein. In the 1970s, after a decade from the purification of cyclosporine, a selective immunosuppressant agent and potent tool in transplantation medicine, a novel molecule was purified from bacteria Streptomyces tsukubaensis.

2024年11月6日 · FKBP4, a member of the FK506-binding protein (FKBP) family, is a promising target for a variety of disorders, including cancer. However, its underlying molecular mechanism and potential...

2025年1月15日 · Here, we report a split-Csy4 architecture that was carefully optimized for in vivo usage. First, we separated Csy4 into two independent protein moieties whose full catalytic activity can be restored via various constitutive or conditional protein dimerization systems.