2024年12月25日 · FGF4 (Fibroblast Growth Factor 4) is a Protein Coding gene. Diseases associated with FGF4 include Embryonal Carcinoma and Germ Cell Cancer. Among its related pathways are Downstream signaling of activated FGFR2 and Apoptotic Pathways in …

The mitogenic and cytoprotective properties of FGF7 are already being put to advantageous use in the clinic. Other FGFs, including FGF1, FGF2 and FGF4, have been tested in clinical trials and may eventually be used to treat cardiovascular disease.

Here, we report that the differentiation of robust proportions of epiblast-like and primitive endoderm-like cells in mouse embryonic stem cell cultures emerges at the population level through cell-cell communication via a short-range fibroblast growth factor 4 (FGF4) signal.

2024年9月18日 · Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity. Fibroblast growth factor 4 and its novel splice isoform have opposing effects on the maintenance of …

Fgf4, also called “human stomach cancer transforming factor-1” (hst-1), was discovered when DNA from stomach tissues was shown to induce the malignant transformation of fibroblasts. The same oncogene was isolated by transfection of Kaposi sarcoma DNA and is therefore also called “kaposi sarcoma Fgf ” ( kFgf ).

2024年12月18日 · FGF4 shares around 30% sequence identity with the FGF1 and FGF2. Unlike FGF1 and FGF2, FGF4 has a classical signal peptide and thus is efficiently secreted from cells. FGF4 binds and activates the IIIc splice forms of FGFR1 to FGFR3.

FGF4 ameliorates the liver inflammation by reducing M1 macrophage polarization in experimental autoimmune hepatitis. FGF4 Promotes Skin Wound Repair through p38 MAPK and GSK3beta-Mediated Stabilization of Slug. FGF4 improves hepatocytes ferroptosis in autoimmune hepatitis mice via activation of CISD3.

2025年1月4日 · Title: The oncoprotein HBXIP up-regulates FGF4 through activating transcriptional factor Sp1 to promote the migration of breast cancer cells. Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity.

The Fgf1, Fgf4, Fgf7, Fgf8, and Fgf9 subfamily genes encode secreted canonical FGFs, which bind to and activate FGFRs with heparin/HS as a cofactor. The Fgf15/19 subfamily members encode endocrine FGFs, which bind to and activate FGFRs with the …

Fibroblast growth factors (FGFs) signal through FGF receptor tyrosine kinases to regulate a wide range of biological processes during development and adulthood. FGF receptors (FGFRs) are...