
FANCD2 Gene - GeneCards | FACD2 Protein | FACD2 Antibody
2024年12月25日 · FANCD2 (FA Complementation Group D2) is a Protein Coding gene. Diseases associated with FANCD2 include Fanconi Anemia, Complementation Group D2 and Fanconi …
FANCD2–FANCI surveys DNA and recognizes double- to single …
2024年7月31日 · Nature - FANCD2–FANCI is a sliding clamp that diffuses on double-stranded DNA but stalls when it reaches a single-stranded gap, providing a unified molecular …
FANCD2 FA complementation group D2 [ (human)] - National …
FANCD2-FANCI surveys DNA and recognizes double- to single-stranded junctions. Pancancer analysis of the prognostic and immunological role of FANCD2: a potential target for …
The Fanconi Anemia/BRCA Pathway: FANCD2 at the Crossroad …
Available data indicate that FANCD2 is involved in cell cycle regulation and DNA repair. Our current knowledge on the functional significance of FA pathway and more specifically FANCD2 …
FANCD2–FANCI is a clamp stabilized on DNA by ... - Nature
2020年2月17日 · FANCD2–FANCI adopts a closed conformation when the FANCD2 subunit is monoubiquitinated, creating a channel that encloses double-stranded DNA (dsDNA). Ubiquitin …
Fancd2 in vivo interaction network reveals a non-canonical role in ...
Fancd2 is a component of the Fanconi anemia (FA) DNA repair pathway, which is frequently found defective in human cancers. The full repertoire of Fancd2 functions in normal …
FANCD2 and DNA Damage - PubMed
2017年8月19日 · Among those studies, FA group D2 protein (FANCD2) has emerged as the focal point of FA signaling and plays crucial roles in multiple aspects of cellular life, especially in the …
FANCD2 modulates the mitochondrial stress response to prevent …
2021年1月29日 · We show that FANCD2, a master regulator of CFS stability, dampens the activation of the mitochondrial stress response and prevents mitochondrial dysfunction.
The FANCI/FANCD2 complex links DNA damage response to R …
Fanconi anemia (FA) is characterized by congenital abnormalities, bone marrow failure, and cancer susceptibility. The central FA protein complex FANCI/FANCD2 (ID2) is activated by …
DNA repair protein FANCD2 has both ubiquitination-dependent …
2023年3月1日 · When DNA interstrand crosslink lesions occur, a core complex of Fanconi anemia proteins promotes the ubiquitination of FANCD2 and FANCI, which recruit downstream factors …
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