2024年12月25日 · FABP5 (Fatty Acid Binding Protein 5) is a Protein Coding gene. Diseases associated with FABP5 include Psoriasis and Autism Spectrum Disorder . Among its related pathways are Innate Immune System and Developmental Cell Lineages .

Fatty acid-binding protein, epidermal is a protein that in humans is encoded by the FABP5 gene. [5] [6]

fabp5是一个15-kda的细胞质小蛋白，主要参与细胞浆内fa的摄取、运输和代谢。巨噬细胞在过敏性气道炎症(aai)中发挥重要作用。但迄今为止， 脂质伴侣蛋白 fabp5在与过敏性哮喘相关的替代激活的巨噬细胞（m2）中的作用和相关机制尚未阐明。

2022年11月16日 · 该研究发现，脂肪酸结合蛋白fabp5主要通过调节长链不饱和脂肪酸(lcufas) -pparγ-atp-stat6通路调节巨噬细胞m2极化，进而调节过敏性哮喘。

2024年4月23日 · In clear cell renal cell carcinoma, FABP5 binds transported fatty acids and their derivatives, thereby exerting a pro-proliferative role together with poor prognosis, while silencing FABP5...

2 天之前 · FABP5 levels in serum (patient), tumor (PDX and HCC1806 xenografts) and TIF (from HCC1806 xenografts) were ascertained using the Human FABP-5 ELISA kit (Invitrogen, EH178RB) according to the manufacturer’s instructions. Briefly, 100 μl sample and standards were added to appropriate wells precoated with an FABP5 capture antibody.

FABP5 promotes lipolysis of lipid droplets, de novo fatty acid synthesis and activation of NF-kappaB signaling in cancer cells. Although FABP5 facilitates brain endothelial cell uptake of fatty acids, it has limited effects on brain endothelial cell uptake.

2020年10月30日 · Communications Biology - Seo et al. identify fatty acid-binding protein 5 (FABP5) as a booster of HIF-1α activity. They find that oleic-acid treatment activates the FABP5/HIF-1α axis,...

2024年11月1日 · Fatty acid binding protein 5 (FABP5) is a lipid chaperone highly expressed in macrophages. FABP5 deletion is implicated in driving macrophages toward an anti-inflammatory phenotype, yet signaling pathways regulated by macrophage-FABP5 have not been systematically profiled.

1 天前 · FABP5直接结合到mTOR的调控相关蛋白（Raptor）上，增强功能性mTORC1的形成和底物结合，最终汇聚到mTOR信号传导增加和增殖上。 与受体阳性乳腺癌患者相比，三阴性乳腺癌患者的肿瘤和血清中FABP5蛋白的含量增加，这突出了其作为生物标志物的潜在作用，可介导该 ...