2024年12月25日 · ETS1 (ETS Proto-Oncogene 1, Transcription Factor) is a Protein Coding gene. Diseases associated with ETS1 include Jacobsen Syndrome and Hematologic Cancer. Among its related pathways are Cellular responses to stimuli and Cellular Senescence.

In adult humans, Ets1 is expressed at high levels mainly in immune tissues such as thymus, spleen, and lymph node (B cells, T cells, NK cells, and NK T cells and non-lymphoid immune cells). An enforced expression of Ets1 blocks differentiation of B- and T-cells. By contrast, knocking Ets1 down causes multiple defects in the immune system.

Here we review and summarize the general features of Ets1 and describe its roles in immunity and autoimmunity, with a focus on its roles in B lymphocytes. We also review evidence that suggests that Ets1 may play a role in malignant transformation of hematopoietic malignancies including B cell malignancies.

ETS1 is a novel transcriptional regulator of adult T-cell leukemia/lymphoma of North American descent. ETS1 governs pathological tissue-remodeling programs in disease-associated fibroblasts. Regulation of MMP9 transcription by ETS1 in immortalized salivary gland epithelial cells of patients with salivary hypofunction and primary Sjogren's syndrome.

ETS原癌基因1（ETS-1）是ETS转录因子家族的成员之一，在肿瘤和炎症等方面发挥重要作用。 在炎症性肠病（IBD）和结肠炎相关性结直肠癌（CAC）中，ETS-1通过诱导炎症反应、破坏肠上皮细胞屏障和增强癌细胞侵袭性等加快疾病的进展。 为探索IBD及CAC的发病机制及潜在治疗靶点，本文就ETS-1在IBD及CAC中的研究进展作一综述。 引用本文: 孙绪凡, 靳桂媛, 马翠梅, 等. ETS-1在炎症性肠病及结肠炎相关性结直肠癌中的研究进展 [J] . 中华炎性肠病杂志（中英文）, …

2022年8月23日 · Nature Immunology - Tissue-destructive fibroblasts in arthritis are driven by the transcription factor ETS1. Analysis of a cross-tissue, single-cell fibroblast dataset and genetic...

Here we review and summarize the general features of Ets1 and describe its roles in immunity and autoimmunity, with a focus on its roles in B lymphocytes. We also review evidence that suggests that Ets1 may play a role in malignant transformation of hematopoietic malignancies including B cell malignancies.

2020年5月4日 · RNA测序结合染色质免疫沉淀 (ChIP-seq)的全基因组转录组分析显示，人类ETS1可直接诱导控制NK细胞分化的关键转录因子E4BP4、TXNIP、TBET、GATA3、HOBIT和BLIMP1的表达。 此外，ETS1还调控凋亡和NK细胞活化相关基因的表达。 本研究揭示了ETS1作为人类NK细胞发育和终末分化的重要调控因子的分子机制。 原始出处： Sylvie Taveirne，et al. The transcription factor ETS1 is an important regulator of human NK cell development and …

该基因编码 ETS 转录因子家族的成员，其定义为存在一个保守的 ETS DNA 结合域，该域识别目标基因中的核心共有 DNA 序列 GGAA/T。 这些蛋白质作为许多基因的转录激活因子或抑制因子发挥作用，并参与干细胞发育、细胞衰老和死亡以及肿瘤发生。 已针对该基因描述了编码不同亚型的可变剪接转录物变体。 [RefSeq 提供，2011 年 7 月]

2022年4月29日 · We found that the down-regulation is likely controlled by ETS1 (ETS proto-oncogene 1), a transcription factor down-regulated in LLIs and positively coexpressed with most ribosomal protein genes (RPGs).