EPH receptor A2 (ephrin type-A receptor 2) is a protein that in humans is encoded by the EPHA2 gene. [5][6] This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system.

Dec 25, 2024 · EPHA2 (EPH Receptor A2) is a Protein Coding gene. Diseases associated with EPHA2 include Cataract 6, Multiple Types and Aniridia. Among its related pathways are GPCR Pathway and ERK Signaling.

Nov 13, 2024 · In this review, we summarize the main mechanisms underlying EphA2 dysregulation in cancer, highlighting its molecular complexity. Then, we analyze therapies that have been developed over time to counteract its action.

Aug 18, 2020 · Overall, EphA2 represents a potential target for treating malignant tumors. Ephrin receptors (Eph) represent the most important class of receptor tyrosine kinases (RTKs) [1]. EphA1, the firstly described Eph receptor, was identified in liver cancer cells while screening for RTKs in 1987 [2].

Aug 18, 2020 · The tyrosine kinase EphA2, which belongs to the family of Eph receptors, is highly produced in tumor tissues, while found at relatively low levels in most normal adult tissues, indicating its potential application in cancer treatment.

Apr 20, 2021 · Ephrin type-A receptor 2 (EphA2), a receptor tyrosine kinase, is overexpressed in human breast cancers often linked to poor patient prognosis. Accumulating evidence demonstrates that EphA2 plays important roles in several critical processes associated with malignant breast progression, such as proli …

Dec 2, 2021 · EphA2 promotes cancer malignancy through a poorly understood non-canonical form of signaling involving serine/threonine phosphorylation of the linker connecting its kinase and SAM domains.

Nov 7, 2024 · One potential target is EphA2, although paradoxically, pro- and anti-oncogenic effects have been shown to be mediated by EphA2. We demonstrate that unique activating and blocking EphA2-targeting...

EphA2 Is a Lung Epithelial Cell Receptor for Pneumocystis beta-Glucans. EPHA2 mediates PDGFA activity and functions together with PDGFRA as prognostic marker and therapeutic target in glioblastoma. CircPAG1 Inhibits the High Glucose-Induced Lens Epithelial Cell Injury by Sponging miR-630 and Upregulating EPHA2.

Recent analyses have revealed that the EphA2 receptor is a key modulator for a wide variety of cellular functions. This review focuses on the roles of EphA2 in both development and disease. Keywords: EphA2, ephrin, development, cataract, kidney, …