Gamma-enolase, also known as enolase 2 (ENO2) or neuron specific enolase (NSE), is an enzyme that in humans is encoded by the ENO2 gene. [5] [6] Gamma-enolase is a phosphopyruvate hydratase. Gamma-enolase is one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin.

2024年12月24日 · ENO2 (Enolase 2) is a Protein Coding gene. Diseases associated with ENO2 include Glycogen Storage Disease Due To Muscle Beta-Enolase Deficiency and Granular Cell Tumor. Among its related pathways are glycolysis (BioCyc) and Gluconeogenesis.

2023年9月4日 · Here, we identify the glycolytic enzyme enolase 2 (ENO2) as a driver of resistance to antiangiogenic therapy in colorectal cancer (CRC) mouse models and human participants. ENO2 overexpression...

Enolase 2 (ENO2), a crucial glycolytic enzyme in cancer metabolism, is associated with the metastasis of multiple cancers and is also used as a marker for neuroendocrine tumours. However, its role in PCa metastasis remains unclear.

Functional studies demonstrated that ENO2 promoted cell growth, glycolysis, and glucocorticoid resistance, all of which were effectively inhibited when ENO2 was silenced with shRNAs. Further studies revealed that ENO2 up-regulated various glycolysis-related genes and enhanced Akt activity with subsequent glycogen synthase kinase3β (GSK-3β ...

2025年1月6日 · Here, we demonstrate that ENO2 facilitates macrophage polarization in a catalytic activity-dependent manner and facilitates HNSCC metastasis, suggesting that ENO2, a previously underestimated enolase, may play a critical role in tumor progression.

ENO2 is upregulated in lung cancer tissues and linked to the prognosis. It can be used as a therapeutic target for developing lung cancer drugs.

ENO2 Promotes Colorectal Cancer Metastasis by Interacting with the LncRNA CYTOR and Activating YAP1-Induced EMT. Brain damage markers neuron-specific enolase (NSE) and S100B in serum in children with Lyme neuroborreliosis-detection and evaluation as prognostic biomarkers for clinical outcome.

Collectively, this study highlights the pivotal role of ENO2 in the metabolic regulation and functional maintenance of vascular endothelial cells and suggests that targeting ENO2-induced glycolysis is a promising therapeutic strategy for managing neovascularization.

2024年7月10日 · Enolase 2 (ENO2), a crucial glycolytic enzyme in cancer metabolism, is associated with the metastasis of multiple cancers and is also used as a marker for neuroendocrine tumours. However, its role in PCa metastasis remains unclear.