Dec 24, 2024 · ELOVL1 (ELOVL Fatty Acid Elongase 1) is a Protein Coding gene. Diseases associated with ELOVL1 include Ichthyotic Keratoderma, Spasticity, Hypomyelination, And Dysmorphic Facial Features and Spinocerebellar Ataxia 38 .

Elovl1缺陷的T细胞中饱和长链脂肪酸（VLCFAs）的减少介导了INSIG1的不稳定性和SREBP2的激活，使T细胞激活和增殖得到改善。 Elovl1缺陷通过增强线粒体功能和脂肪酸氧化，帮助T细胞抵御肿瘤微环境的代谢压力。 研究背景 . 免疫疗法在过去几十年中彻底改变了癌症治疗。

Nov 20, 2023 · The ELOVL1 gene encodes an enzyme responsible for the elongation of fatty acids, including very-long-chain fatty acids, which are crucial for maintaining the epidermal barrier. Mutations in ELOVL1 result in decreased levels of very-long-chain fatty acids and compromised lipid barrier function, contributing to the development of ARCI [ 41 ].

Mar 10, 2025 · Our integrative approach unveiled the elongation of very long-chain fatty acid protein 1 (Elovl1), a gene encoding for a key enzyme for the synthesis of saturated very long-chain fatty acids...

超长链脂肪酸延伸酶 (elongase of verylong chain fatty acids,ELOVL)家族是哺乳动物中一类编码超长链脂肪酸 (very long chain fatty acids,VLCFA)延伸酶的基因家族。 该家族有7个成员:ELOVL1～7。 各个成员编码的蛋白质参与不同长度脂肪酸链的延长,对脂肪酸的代谢进行调控,进而发挥其生物学功能。 本文就该家族成员的结构、生物学功能及表达调控进行综述。 百度学术集成海量学术资源，融合人工智能、深度学习、大数据分析等技术，为科研工作者提供全面快捷的 …

超长链脂肪酸延长酶 (ELOVL) 家族在脂质代谢和细胞功能中发挥着重要作用。 这篇全面的综述探讨了各个 ELOVL 同工型的结构特征、功能特性和生理意义，为脂质生物合成、细胞膜动力学和信号通路提供了见解。 本综述旨在强调 ELOVL 家族在正常生理和疾病发展中的重要性。 通过综合当前的知识，我们强调了 ELOVL 作为潜在治疗靶点的相关性。 我们强调 ELOVL 表达失调与疾病之间的关联，包括代谢紊乱、皮肤病、神经退行性疾病和癌症。 ELOVL 在癌症生物学（从肿瘤 …

Mar 11, 2025 · Elovl1是编码饱和超长链脂肪酸（VLCFAs）合成关键酶的基因。在 CD8 + T 细胞中，Elovl1的缺失会导致饱和 VLCFAs 的减少，进而影响细胞的脂质组成。脂质组学分析显示，Elovl1缺失的 CD8 + T 细胞中，含有 C 22 - C 26 的 VLCFAs 脂质减少，而含有较短脂肪酸链（C 16 - C 18 ）的 ...

Feb 9, 2025 · ELOV1 promotes very long-chain fatty acid accumulation X-linked adrenoleukodystrophy and is inhibited by CoA esters of bezafibrate and gemfibrozil. Results suggest that inhibition of atty acid elongase 1 (ELOVL1) may be an underlying mechanism by which Lorenzo's oil exerts its action.

Mar 1, 2025 · ELOVL1 exhibits ubiquitous expression with moderate expression in the brain, preferring saturated C18-C24 FAs, particularly C20-C22 VLCFAs, and is responsible for synthesizing C24 VLCFAs. ELOVL1 also elongates monounsaturated C20:1 and branched-chain VLCFAs, showing redundancy with ELOVL3 and ELOVL7 [18, 19].

Mar 10, 2025 · A new study identifies a mechanism by which Elovl1 deletion disrupts the canonical feedback inhibition of cholesterol synthesis in T cells. By fundamentally rewiring cholesterol metabolism, Elovl1 ...