2024年12月24日 · ELOVL1 (ELOVL Fatty Acid Elongase 1) is a Protein Coding gene. Diseases associated with ELOVL1 include Ichthyotic Keratoderma, Spasticity, Hypomyelination, And Dysmorphic Facial Features and Spinocerebellar Ataxia 38. Among its related pathways are Fatty acid metabolism and docosahexaenoate biosynthesis IV (4-desaturase, mammals).

2023年11月20日 · The family of very-long-chain fatty acid elongases (ELOVL1-ELOVL7) plays a crucial role in cellular metabolism by facilitating the elongation of fatty acids beyond the typical chain length.

Seven elongases, ELOVL1–7, have been identified in mammals and each has a unique substrate specificity. Researchers have recently developed a keen interest in the elongation of very long chain fatty acids protein 1 (ELOVL1) enzyme as a potential treatment for a variety of diseases.

2025年2月9日 · ELOV1 promotes very long-chain fatty acid accumulation X-linked adrenoleukodystrophy and is inhibited by CoA esters of bezafibrate and gemfibrozil. Results suggest that inhibition of atty acid elongase 1 (ELOVL1) may be an underlying mechanism by which Lorenzo's oil exerts its action.

2015年2月1日 · ELOVL1 is the key enzyme in the elongation of C22:0 to C26:0 and to study it at the enzyme level, we generated an ELOVL1 over-expression model using HEK293 Flp-In cells. After transfection individual clones were isolated and characterized by western blot analysis.

2023年3月8日 · Seven elongases, ELOVL1–7, have been identified in mammals and each has a unique substrate specificity. Researchers have recently developed a keen interest in the elongation of very long chain fatty acids protein 1 (ELOVL1) enzyme as a potential treatment for a variety of diseases.

2025年3月10日 · Elovl1-deficient T cells increased mitochondrial fitness and fatty acid oxidation, thus withstanding the metabolic stress imposed by the tumour microenvironment. Finally, ELOVL1 in CD8+ T cells ...

2021年6月10日 · To understand the molecular basis of acyl chain elongation by the ELOVL elongases, we purified and solved the crystal structure of human ELOVL7 in complex with a copurified, covalently bound...

2010年10月26日 · Particularly notable was the high activity exhibited by ELOVL1 toward saturated and monounsaturated C20- and C22-CoAs, and that it was essential for the production of C24 sphingolipids, which are unique in their capacity to interdigitate within the membrane as a result of their long chain length.

2024年3月5日 · Title: Dominant ELOVL1 mutation causes neurological disorder with ichthyotic keratoderma, spasticity, hypomyelination and dysmorphic features. ELOV1 promotes very long-chain fatty acid accumulation X-linked adrenoleukodystrophy and is inhibited by CoA esters of bezafibrate and gemfibrozil.