Dec 24, 2024 · EIF3F (Eukaryotic Translation Initiation Factor 3 Subunit F) is a Protein Coding gene. Diseases associated with EIF3F include Intellectual Developmental Disorder, Autosomal Recessive 67 and Neurodevelopmental Disorder With …

Mar 18, 2021 · An identical homozygous missense variant in EIF3F, identified through a large-scale genome-wide sequencing approach, was reported as causative in nine individuals with a neurodevelopmental disorder, characterized by variable intellectual disability, epilepsy, behavioral problems and sensorineural hearing-loss.

Part of eukaryotic translation initiation factor 3 complex. Implicated in autosomal recessive non-syndromic intellectual disability. [provided by Alliance of Genome Resources, Apr 2022]

eIF3f mediates restriction of HIV-1 expression through a set of factors that includes eIF3f, the SR protein 9G8, and the cyclin-dependent kinase 11 (CDK11). eIF3f may inhibit translation by increasing the binding to the eIF3 complex during apoptosis. eIF3f specifically interferes with the 3' end processing of HIV-1 mRNAs

Aug 11, 2023 · 导读： eIF3f，以前称为翻译起始因子eIF3的亚基之一，是一种不仅在翻译起始中起作用，而且在基因调控和疾病中起作用的蛋白质。 它实际上与泛素介导的蛋白质降解机制有关，以调节与癌症有关的重要靶点。 然而，eIF3f的上游稳压器和下游目标尚未完全表征。 8月6日，中山大学李孟鸿、孟祥祺共同通讯在《Advanced Science》上发表题为“eIF3f Mediates SGOC Pathway Reprogramming by Enhancing Deubiquitinating Activity in Colorectal Cancer”， 该研 …

eIF3（eukaryotic initiation factor 3，真核起始因子3）是最大的真核起始因子，在哺乳动物细胞中，其分子量超过了600KDa。 eIF3是真核翻译起始进程中起着核心作用。 例如，eIF3可以使eIF2·GTP·Met-tRNAi三联体复合物稳定地结合到40S核糖体亚基上，并促使43S前起始复合物的形成；它能够通过促进mRNA与40S亚基结合；而且，它还可以与游离的40S亚基结合，影响40S亚基与60S亚基及其他eIF的结合或解离等等。

Mar 15, 2006 · 我们首次证明，使用癌症谱分析芯片可在大多数人类肿瘤中下调eIF3f的表达，并通过实时逆转录PCR在黑色素瘤和胰腺癌中得到证实。 eIF3f的过表达抑制黑素瘤和胰腺癌细胞的细胞增殖并诱导细胞凋亡。 沉默eIF3f可保护黑素瘤细胞免于凋亡。 我们进一步研究了eIF3f的生物学功能。 体外翻译研究表明，eIF3f是翻译的负调节子，eIF3f的氨基酸170和248之间的区域是其翻译调节功能所必需的。 eIF3f的异位表达抑制翻译和总体细胞蛋白合成。 核糖体谱和核糖 …

Mar 18, 2021 · Background: An identical homozygous missense variant in EIF3F, identified through a large-scale genome-wide sequencing approach, was reported as causative in nine individuals with a neurodevelopmental disorder, characterized by variable intellectual disability, epilepsy, behavioral problems and sensorineural hearing-loss. To refine the ...

Aug 4, 2024 · Enables deubiquitinase activity and identical protein binding activity. Contributes to translation initiation factor activity. Involved in IRES-dependent viral translational initiation; protein deubiquitination; and translational initiation. Located in membrane. Part of eukaryotic translation initiation factor 3 complex.

In this manuscript, we discuss the interactome and function of each subunit of the human eIF3 complex. Furthermore, we review how altered levels of eIF3 subunits correlate with neurodegenerative disorders and cancer onset and development; in addition, we evaluate how such misregulation may also trigger infection cascades.