EGR-1 (Early growth response protein 1) or NGFI-A (nerve growth factor-induced protein A) is a protein that in humans is encoded by the EGR1 gene. EGR-1 is a mammalian transcription factor. It was also named Krox-24, TIS8, and ZENK. It was originally discovered in mice.

Dec 24, 2024 · EGR1 (Early Growth Response 1) is a Protein Coding gene. Diseases associated with EGR1 include Myelodysplastic Syndrome and Ischemia. Among its related pathways are PIP3 activates AKT signaling and Hepatocyte growth factor receptor signaling.

Nov 17, 2023 · egr1 可减轻炎症增强剂的作用，并减缓巨噬细胞的炎症反应. 作者的数据显示，egr1 与巨噬细胞发育过程中（第 3 至 4 天）一组约 1600 个增强子的转录抑制有关。作者开始确定 egr1 抑制活性的生物学意义。

2024年1月17日华中农业大学动科动医学院陈焕春院士、王湘如教授团队在期刊Cell Communication and Signaling（IF:8.4）发表了题为“Egr-1 is a key regulator of the blood-brainbarrier damage induced by meningiticEscherichia coli”的研究论文。该研究结果表明Egr-1依赖性机制是脑膜炎型大肠杆菌破坏 血脑屏障 的途径，为细菌性脑膜 ...

Egr1 is a novel regulator of stathmin expression and p53 mediates the transcriptional repression of stathmin by Egr1 in human lung cancer cells. Egr-1 might play an important role in the up-regulation of VEGF and IL-8 induced by HGF and contribute to HGF-mediated angiogenesis, which might be promising targets for hepatocellular carcinoma therapy.

Sep 2, 2005 · Recent studies are reviewed indicating that the transcription factor early growth response-1 (Egr1) is a direct regulator of multiple tumor suppressors including TGFβ1, PTEN, p53, and...

Nov 10, 2021 · Oxidative stress-induced EGR1 upregulation promotes NR4A3-mediated nucleus pulposus cells apoptosis in intervertebral disc degeneration, Aging, 16, 12, (10216-10238), (2024). https://doi.org/10.18632/aging.205920

Jan 13, 2021 · Here, we analyze the molecular determinants of monocytic and macrophagic commitment by profiling the EGR1 transcription factor. EGR1 is essential for monopoiesis and binds enhancers that regulate monocytic developmental genes such as CSF1R. However, differentiating macrophages present a very different EGR1 binding pattern.

Jun 14, 2024 · We identified early growth response protein 1 (Egr1) as a regulator of regenerative senescence in both models. In the neonatal heart, Egr1 facilitates angiogenesis and cardiomyocyte...

Mar 24, 2021 · Early growth response factor 1 (EGR1) is a transcription factor that is mainly involved in the processes of tissue injury, immune responses, and fibrosis. Recent studies have shown that EGR1 is closely related to the initiation and progression of cancer and may participate in tumor cell proliferatio …