EGLN2 Gene - GeneCards | EGLN2 Protein | EGLN2 Antibody
Dec 24, 2024 · EGLN2 (Egl-9 Family Hypoxia Inducible Factor 2) is a Protein Coding gene. Diseases associated with EGLN2 include Pheochromocytoma and Polycythemia. Among its …
EGLN2 - Wikipedia
ELGN2 is an alpha-ketoglutarate-dependent hydroxylase, a superfamily of non-haem iron-containing proteins. The hypoxia inducible factor (HIF) is a transcriptional complex which is …
EGLN2 egl-9 family hypoxia inducible factor 2 [ (human)]
Feb 8, 2025 · The identification of EGLN2 as a significantly deregulated gene that maps within the paired chromosome region directly implicates defects in the oxygen-sensing network to the …
egl-9 家族缺氧诱导因子 2（EGLN2）基因 | MCE
缺氧诱导因子 (HIF) 是一种参与氧稳态的转录复合物。 在正常氧气水平下， HIF 的 α 亚基被脯氨酰羟基化作用靶向降解。 该基因编码负责这种翻译后修饰的酶。 可变剪接导致多个转录本变体 …
脯氨酰羟化酶1（PHD1 / EGLN2）的表达抑制缺氧 ... - X-MOL
这些数据表明通过激活HIF羟化酶抑制缺氧诱导的HIF-1α激活可以提供一种抑制肿瘤生长和新生血管形成的新治疗策略，并支持基于激活HIF脯氨酰羟化酶的基因转移方法的发展。 缺氧应激是 …
Targeting EGLN2/PHD1 protects motor neurons and normalizes …
Sep 9, 2024 · Germeys et al. identify EGLN2 as an ALS target that, when downregulated, protects motor neurons and mitigates the ALS phenotype in ALS zebrafish and mice. Using snRNA-seq …
EGLN2 DNA methylation and expression interact with HIF1A to …
EGLN2 encodes the oxygen-sensing enzyme prolyl hydrolase 1 (PHD1) responsible for mediating the HIF-1α degradation and related to tumor progression. EGLN2 is implicated as a tumor …
Egln2 egl-9 family hypoxia-inducible factor 2 [ (house mouse)]
Feb 8, 2025 · Endothelial prolyl hydroxylase 2 is necessary for angiotensin II-mediated renal fibrosis and injury. PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by …
EGLN 家族脯氨酰羟化酶在癌症中的多方面作用：超越 HIF 调 …
egln1、egln2和egln3是脯氨酸羟化酶，其主要功能是调节hif因子。它们作为氧传感器工作，是常氧环境中 hifα 亚基降解的主要负责人。由于它们的活动严格依赖于氧，当氧张力降低时，它们对 …
EglN2 contributes to triple negative breast tumorigenesis by ...
Jan 24, 2017 · EglN2 contributes to ERα-positive breast tumorigenesis by acting as an estrogen-inducible gene. However, the detailed molecular mechanism(s) underlying the post …
- Some results have been removed