The EP300 gene is located on the long (q) arm of the human chromosome 22 at position 13.2. This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. EP300 is closely related to another gene, CREB binding protein, which is found on human chromosome 16.

2024年12月25日 · EP300 (E1A Binding Protein P300) is a Protein Coding gene. Diseases associated with EP300 include Rubinstein-Taybi Syndrome 2 and Menke-Hennekam Syndrome 2. Among its related pathways are Nuclear events mediated by NFE2L2 and RNA Polymerase I Promoter Opening.

The EP300 gene provides instructions for making a protein called p300, which regulates the activity of many genes in tissues throughout the body. Learn about this gene and related health conditions.

2009年2月10日 · Forms a complex made of CDK9, CCNT1/cyclin-T1, EP300 and GATA4 that stimulates hypertrophy in cardiomyocytes (PubMed:20081228). Interacts with IRF1 and this interaction enhances acetylation of p53/TP53 and stimulation of its activity (PubMed: 15509808 ).

The EP300 gene encodes p300, a histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation (Gayther et al., 2000).

Here, we describe a potent, highly selective heterobifunctional degrader of EP300 with biological activity in CBP-deficient and EP300-dependent tumor cells. This compound achieves robust degradation of EP300 in vivo at doses that sustain EP300 degradation with minimal effects on CBP protein level.

2023年2月14日 · CREB-binding protein (CREBBP) and E1A-binding protein P300 (EP300) are two key acetyltransferases and transcriptional cofactors that regulate gene expression by regulating the acetylation levels of histone proteins and non-histone proteins.

It functions as a histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein.

E1A binding protein p300 (EP300) is a gene that encodes a protein that functions in transcriptional regulation by histone acetylation. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift insertions and deletions, and in-frame insertions and deletions are observed in cancers such as endometrial cancer, intestinal cancer ...

2024年11月5日 · EP300/CBP inhibition causes cell cycle arrest and apoptosis in multiple myeloma (MM) models through concomitant suppression of interferon regulatory factor 4 (IRF4) and MYC, highlighting the rationale for targeting EP300/CBP as a novel therapy for MM.