2024年12月24日 · EGR2 (Early Growth Response 2) is a Protein Coding gene. Diseases associated with EGR2 include Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive and Charcot-Marie-Tooth Disease, Demyelinating, Type 1D .

Early growth response 2 (EGR2) is a novel regulator of the senescence programme. Bi-allelic mutations in EGR2 cause autosomal recessive demyelinating neuropathy by disrupting the EGR2-NAB complex. NFAT2 overexpression suppresses the malignancy of hepatocellular carcinoma through inducing Egr2 expression.

2023年7月13日 · Our study shows that EGR2 regulates tissue-specific and disease-specific functions in pathogenic T H 17 cells in the CNS. The differentiation of T H 17 cells is triggered by T cell receptor (TCR)...

2023年7月20日 · Here we identify the transcription factor EGR2 as a key determinant of T H 17 cell pathogenicity. EGR2 was found to govern T H 17 cell migration, regulate the expression of...

Early growth response genes are family of transcription factors comprising of four members, Egr1, Egr2, Egr3 and Egr4. All of which contain three cyc2-His2 zinc fingers. Initially, Egr2 function was identified in the regulation of peripheral nerve myelination, hindbrain segmentation.

EGR2 is a transcription factor essential for the development and maintenance of myelin structure in the nervous system. Mutations in EGR2 can lead to a rare form of Charcot-Marie-Tooth disease (CMT1D) by disrupting DNA binding and transactivation, affecting myelin gene expression.

2020年11月1日 · We identified the TF, early growth response 2 (EGR2), bridging the early transient and late stable gene expression program of polarization. EGR2 is a direct target of IL-4-activated STAT6, having broad action indispensable for 77% of the induced gene signature of alternative polarization, including its autoregulation and a robust, downstream TF ...

2021年3月10日 · While interferon regulatory factor 4 (IRF4) is found to control hallmark dendritic cell functions with less impact on DNA methylation, early growth response 2 (EGR2) proves essential for MO...

The EGR2 gene, a member of the early growth response gene family, encodes a transcription factor that is a prime regulator of Schwann cell myelination. It may also play a role in hindbrain segmentation and development (summary by Szigeti et al., 2007).

2024年12月10日 · Title: Transcription factor EGR2 controls homing and pathogenicity of T(H)17 cells in the central nervous system. Egr2 and 3 maintain anti-tumour responses of exhausted tumour infiltrating CD8 + T cells.