2024年12月24日 · E2F4 (E2F Transcription Factor 4) is a Protein Coding gene. Diseases associated with E2F4 include Colorectal Cancer and Retinoblastoma. Among its related pathways are Aberrant regulation of mitotic G1/S transition in …

Here we review the canonical functions of E2F4 and discuss recent evidence expanding the role of this transcription factor, with a focus on cell fate decisions in tissue homeostasis and regeneration. KEYWORDS: cancer, cell cycle, development, differentiation, E2F, E2F4, RB, regeneration, stem cells.

E2F4, PHACTR3, PRAME family member and CDH12 most probably play important role in non-small-cell lung cancer geneses; E2F4 may be determinant in the promotion of proliferation of human intestinal epithelial crypt cells and colorectal cancer cells.

2019年7月3日 · Here we show that E2F4 is important for the proliferation and the survival of mouse embryonic stem cells. In these cells, E2F4 acts in part as a transcriptional activator that promotes the...

2019年5月3日 · In this Review, we discuss the activities of E2F proteins with an emphasis on the newest atypical E2F family members, the specific and redundant functions of E2F proteins, how misexpression of E2F...

We used ChIP sequencing (ChIP-seq) to identify around 16 000 E2F4 binding sites which potentially regulate 7346 downstream target genes with wide-ranging functions in DNA repair, cell cycle regulation, apoptosis, and other processes.

2023年8月23日 · Replicative stress blunts Trim33-dependent ubiquitination of E2f4, which stimulates transient Recql recruitment to chromatin and facilitates recovery of DNA synthesis.

2024年1月26日 · E2F4 transcription factor is a prognostic biomarker related to immune infiltration of head and neck squamous cell carcinoma. Qi L, et al. Sci Rep, 2022 Jul 15. PMID 35840663, Free PMC Article. E2F4 may be a core transcription factor in the lncRNA-TF regulatory network in cervical cancer.

E2F4 binds p130 and localizes to the nucleus following PC12 cell differentiation. E2F4 interactions with Rb family proteins have a major impact on E2F4 function, including its conversion from a trans-activator into a repressor of E2F-regulated cell cycle genes (22, 39).

We show that E2F4 is fully dispensable for the control of cellular proliferation but it plays a critical role in terminal differentiation. In particular, E2F4 is essential for end stage maturation of erythroid cells, highlighting the importance of the pRB/E2F pathway in the control of erythropoiesis in vivo.