2024年12月24日 · E2F3 (E2F Transcription Factor 3) is a Protein Coding gene. Diseases associated with E2F3 include Retinoblastoma and Glioma Susceptibility 1. Among its related pathways are Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects and Pre-NOTCH Expression and Processing.

Transcription factor E2F3 is a protein that in humans is encoded by the E2F3 gene. [5] The protein encoded by this gene is a member of the E2F family of transcription factors.

e2f靶基因chk1 可以通过磷酸化调节 e2f3、e2f7和e2f8 的活性。 Drosophila melano gaster遗传模型表明，除了诱导典型的凋亡转录程序外，E2F还可以通过控制参与氧化磷酸化和电子传递的线粒体相关基因的表达来参与细胞凋亡。

2024年9月19日 · E2F3是推动细胞进入S期的关键转录因子之一。 其功能主要集中在G1期，通过激. 活参与DNA复制和细胞周期进展的基因，促进细胞进入S期。 在细胞周期的G1期早. 期，E2F3通常与Rb蛋白结合，形成抑制复合体，阻止其转录激活功能。 Rb-E2F3复合体的调控：在G1期早期，E2F3通过与Rb蛋白结合受到抑制。 当细胞. 进入G1期晚期时，细胞周期依赖性激酶（CDKs）磷酸化Rb蛋白，使其与E2F3分. 离，E2F3得以释放并激活其靶基因。 激活S期基因：E2F3主要 …

E2F3 may be a potential target gene of miR-125a-5p in gastric cancer. Our findings may be helpful in exploring the underlying mechanisms of CML and provide useful information in cancer treatment. High E2F3 expression is associated with hepatocellular carcinoma. miR-141 suppresses the growth and metastasis of HCC cells by targeting E2F3.

该基因编码一个转录因子小家族的成员，该家族通过结合 DP 相互作用伙伴蛋白发挥作用。 编码的蛋白质识别 DNA 中的特定序列基序，并直接与视网膜母细胞瘤蛋白 (pRB) 相互作用，以调节参与细胞周期的基因的表达。 已在许多人类癌症中观察到该基因的拷贝数和活性发生改变。 该基因在 2 号和 17 号染色体上存在假基因。 可变剪接导致多个转录本变异。 [RefSeq 提供，2013 年 3 月] This gene encodes a member of a small family of transcription factors that function through …

E2F3 is a transcription factor that may initiate tumorigenesis if overexpressed. Previously, we demonstrated that E2F3 mRNA is overexpressed in breast cancer and that E2F3 overexpression results in centrosome amplification and unregulated mitosis, which can promote aneuploidy and chromosome instability to initiate and sustain tumors.

2019年1月3日 · Here we show that E2F3d, a previously unidentified E2F3 isoform, mediates hypoxia-induced mitophagy in cancer cells. Aberrant activity and expression of the E2F3 transcription factor is...

2015年4月24日 · Our findings implicate the cell cycle pathway as a widespread regulator of cell fate genes, and suggest that E2f3 proteins control cell type-specific differentiation programs by regulating unique...

2024年11月17日 · E2F3 transcription factor: A promising biomarker in lung cancer. Al Ahmed HA, Nada OAl Ahmed HA, et al. Cancer Biomark, 2017. PMID 28269748; E2F3 is the main target gene of the 6p22 amplicon with high specificity for human bladder cancer. Oeggerli M, Schraml P, Ruiz C, Bloch M, Novotny H, Mirlacher M, Sauter G, Simon ROeggerli M, et al ...