Dec 24, 2024 · E2F1 (E2F Transcription Factor 1) is a Protein Coding gene. Diseases associated with E2F1 include Retinoblastoma and Squamous Cell Carcinoma. Among its related …

E2F proteins regulate the transcription of S phase cyclins and genes required for DNA replication, DNA repair, and apoptosis. The activity of E2F1, the archetypal and most heavily studied E2F …

E2F1 shows structural homology with other E2F activators. It has a single DNA binding domain and heterodimerizes with a dimerization partner (DP1/DP2) in order to effectively bind DNA …

May 3, 2019 · This study shows that minor copy number changes (one to two extra copies) of E2f1 or E2f3b are sufficient to induce liver cancer in mice.

Nov 10, 2017 · We summarize recent findings about the cell cycle-independent roles of E2F1 in various tissues that contribute to global metabolic homeostasis and highlight that E2F1 activity …

Sep 18, 2019 · In this study, we show that E2F1 regulates gene expression for HR factors and DNA replication. We also demonstrate an essential role for the HR pathway in colon cancer …

E2F1 has a cancer protective role in oncogenic BRAF-activated melanoma cells. E2F1 promotes the transcription of lncRNA RGMB-AS1 in papillary thyroid carcinoma (PTC). blocking E2F1 …

Using a conditional gene-targeting approach, we show that the targeted disruption of the entire E2F activator subclass composed of E2f1, E2f2, and E2f3 in mouse embryonic fibroblasts …

Feb 9, 2025 · In cultured neurons, HIV-1 gp120 increases transcription factor E2F1 levels in the nucleus, stimulates its transcriptional activity, and enhances the expression of the E2F1 target …

Oct 11, 2022 · E2F1 drives the cell cycle of CRC by promoting spindle assembly, in which E2F1-induced stathmin1 and TACC3 enhance the stability of spindle fiber.