2024年12月24日 · DUSP7 (Dual Specificity Phosphatase 7) is a Protein Coding gene. Diseases associated with DUSP7 include Variola Major. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and MAPK family signaling cascades.

dusp 的特征在于它们能够使酪氨酸和丝氨酸/苏氨酸残基去磷酸化。 dusp7 属于一类 dusp，称为 mkp，可使 mapk (丝裂原活化蛋白激酶) 蛋白 erk (参见 mim 601795) 、jnk (参见 mim 601158) 和 p38 (参见 mim 600289) 去磷酸化，具有不同于个体的特异性 mkp 蛋白。

DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK, JNK, and p38 with specificity distinct from that of individual MKP proteins.

Here, we have identified the dual-specificity phosphatase 7 (DUSP7), known to display selectivity for ERK2, as important in regulating chromosome alignment. During mitosis, DUSP7 bound to ERK2 and regulated the abundance of active phospho-ERK2 through its phosphatase activity.

DUSP7 inhibits cervical cancer progression by inactivating the RAS pathway. DUSP7 regulates the activity of ERK2 to promote proper chromosome alignment during cell division. While the low expression level of DUSP7 was restricted to patients with positive rheumatoid factor and anti-citrullinated protein antibodies, the altered expression of ...

DUSP7 promotes chromosome alignment in mitosis by regulating the activity of ERK2.A, schematic of IF microscopy experiment performed in (B) and (D). B, overexpression of DUSP7 wild type, but not catalytic dead mutants, leads to chromosome misalignment in metaphase.

Affiliations 1 Shanghai Engineering Research Center of Organ Repair, School of Life Science, Shanghai University, Shanghai, 200444, China.; 2 Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Medicine, Shanghai University, 333 Nan Chen Road, Shanghai, 200444, China.; 3 Cardiovascular Division of the Massachusetts General …

2019年5月30日 · Ubiquitination is critical for controlling protein degradation, activation, and interaction. For DUSPs, ubiquitination induces degradation of eight DUSPs, namely, DUSP1, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, and DUSP16. In addition, protein stability of DUSP2 and DUSP10 is enhanced by phosphorylation.

2016年10月25日 · The mechanisms that abrogate the prophase arrest in mammalian oocytes and reinitiate meiosis are not well understood. Here, we identify and characterize an essential pathway for the resumption of meiosis that relies on the protein phosphatase DUSP7. DUSP7-depleted oocytes either fail to resume meiosis or resume meiosis with a significant delay.

Title: DUSP7 regulates the activity of ERK2 to promote proper chromosome alignment during cell division. While the low expression level of DUSP7 was restricted to patients with positive rheumatoid factor and anti-citrullinated protein antibodies, the altered expression of CDC25B correlated with the activity of early arthritis.