2018年1月27日 · The dopamine hypothesis of schizophrenia has moved from the dopamine receptor hypothesis (increased dopamine transmission at the postsynaptic receptors) to a focus on presynaptic striatal hyperdopaminergia.

The dopamine hypothesis of schizophrenia or the dopamine hypothesis of psychosis is a model that attributes the positive symptoms of schizophrenia to a disturbed and hyperactive dopaminergic signal transduction.

2009年3月26日 · We selectively review these data to provide an overview of the 5 critical streams of new evidence: neurochemical imaging studies, genetic evidence, findings on environmental risk factors, research into the extended phenotype, and animal studies.

2024年9月11日 · The dopamine hypothesis of schizophrenia is a scientific theory that suggests dopamine directly contributes to schizophrenia symptoms. Research on this theory and other causes of...

2024年1月23日 · What Is the Dopamine Hypothesis of Schizophrenia? The dopamine hypothesis of schizophrenia was one of the first neurobiological theories for this disease. This theory suggests that an imbalance of dopamine is responsible for schizophrenic symptoms.

2024年8月22日 · The dopamine hypothesis of schizophrenia has been a cornerstone in our understanding of this complex mental disorder for decades. This theory proposes that an imbalance in dopamine neurotransmission plays a crucial role in the development and manifestation of schizophrenia symptoms.

2018年6月29日 · The classical and well-worn theory of psychosis of course is that dopamine hyperactivity in the mesolimbic dopamine pathway at dopamine D2 receptors is the cause of the positive symptoms of schizophrenia, with all antipsychotics acting to block D2 receptors there.

2014年5月18日 · The revised dopamine hypothesis states that dopamine abnormalities in the mesolimbic and prefrontal brain regions exist in schizophrenia. However, recent research has indicated that glutamate, GABA, acetylcholine, and serotonin alterations are also involved in the pathology of schizophrenia.

The “dopamine hypothesis” of schizophrenia arose from the serendipitous discovery by Jean Delay and Pierre Deniker in 1952 of the antipsychotic effects of chlorpromazine, first developed as a presurgical sedative.

The dopamine hypothesis, central to schizophrenia research, suggests heightened dopaminergic transmission as a primary factor in its development, supported by the efficacy of antipsychotic drugs targeting dopamine receptors. However, recent studies have revealed complexities beyond dopamine dysfunction, including the