DBF4 Gene - GeneCards | DBF4A Protein | DBF4A Antibody
Dec 24, 2024 · DBF4 (DBF4-CDC7 Kinase Regulatory Subunit) is a Protein Coding gene. Diseases associated with DBF4 include Ataxia-Telangiectasia and Meier-Gorlin Syndrome 1 . …
DBF4 - Wikipedia
Protein DBF4 homolog A is a protein that is encoded by the DBF4 gene in humans. [5][6][7] DBF4 has been shown to interact with: ORC6L. [8] ^ "Human PubMed Reference:". National Center …
DBF4, not DRF1, is the crucial regulator of CDC7 kinase at …
Aug 8, 2024 · In human cells, the S-phase-promoting kinase CDC7 exists in two alternative complexes: CDC7-DBF4 or CDC7-DRF1. Here, Göder et al. show that while CDC7’s essential …
Dbf4-dependent kinase promotes cell cycle controlled resection …
Apr 3, 2024 · Here, we identify Dbf4-dependent kinase (DDK) as a second major cell cycle regulator of DNA end resection. Using inducible genetic and chemical inhibition of DDK in …
The structural basis of Cdc7-Dbf4 kinase dependent targeting and ...
May 25, 2022 · When Dbf4 is bound to Cdc7 the resulting complex is referred to as Dbf4-dependent Cdc7 kinase (DDK). The complex is regulated through Dbf4, as Dbf4 protein …
Dbf4 - PMC - National Center for Biotechnology Information
Apr 4, 2013 · Dbf4 (Dumbbell former 4 protein) is the regulatory subunit of the Cdc7 kinase which plays critical roles in DNA replication, 1 activation of the replication checkpoint, 2 meiosis, 3 …
Dbf4-Dependent Kinase: DDK-ated to post-initiation events in …
Dbf4-Dependent Kinase (DDK) has a well-established essential role at origins of DNA replication, where it phosphorylates and activates the replicative MCM helicase. It also acts in the …
Dbf4 - SpringerLink
Dbf4 is the activation subunit for Cdc7, a conserved kinase essential for initiation of DNA replication. Dbf4 is evolutionally conserved and carries three conserved motifs, motif-N, -M …
Dbf4 Is Direct Downstream Target of Ataxia Telangiectasia …
Jan 1, 2012 · We demonstrated that ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) proteins directly phosphorylate Dbf4 in response to …
DBF4依赖性激酶在肿瘤发展与治疗中的作用研究进展-期刊-万方数 …
Mar 29, 2024 · dbf4依赖性激酶（ddk）是由dbf4与cdc7结合形成，可激活解螺旋酶，在细胞的复制中发挥重要作用。 DBF4作为调节亚基，还可以通过与其他蛋白结合，直接或间接地激活细胞 …