Apr 24, 2014 · DICER1 tumor predisposition (DICER1) is characterized by an increased risk for pleuropulmonary blastoma (PPB), pulmonary cysts, thyroid gland neoplasia (multinodular goiter, adenomas, and/or thyroid cancer), ovarian tumors (Sertoli-Leydig cell tumor, gynandroblastoma, and sarcoma), and cystic nephroma.

DICER1 syndrome is a genetic disorder associated with an increased risk for developing tumors in the lungs, kidneys, ovaries, thyroid, and several other locations in the body. These growths may be benign (non-cancerous) or malignant (cancerous).

DICER1 syndrome is an inherited disorder that increases the risk of a variety of cancerous and noncancerous (benign) tumors, most commonly certain types of tumors that occur in the lungs, kidneys, ovaries, and thyroid (a butterfly-shaped gland in the lower neck).

DICER1 syndrome is caused by changes in a gene known as DICER1. Genes carry important information that tells our body’s cells how to function. In ways that are not well understood, DICER1 aids in preventing tumors. Most cells of the body carry 2 working copies of the DICER1 gene in their cells.

What is the DICER1 gene? Everyone inherits two copies of the DICER1 gene from their parents, one from their mother and one from their father. This gene works to manage the function of other genes. In most people, this gene works properly.

Dec 24, 2024 · DICER1 (Dicer 1, Ribonuclease III) is a Protein Coding gene. Diseases associated with DICER1 include Global Developmental Delay, Lung Cysts, Overgrowth, And Wilms Tumor and Goiter, Multinodular 1, With Or Without Sertoli-Leydig Cell Tumors. Among its related pathways are Gene Silencing by RNA and MITF-M-dependent gene expression.

DICER1 syndrome is a rare genetic disorder that predisposes individuals to multiple cancer types. Through mutations of the gene encoding the endoribonuclease, Dicer, DICER1 syndrome disrupts the biogenesis and processing of miRNAs with subsequent disruption in control of …

A rare, inherited disorder that is caused by a mutation (change) in a gene called DICER1. Having this mutation increases the risk of certain types of tumors, including tumors of the kidney, thyroid, ovary, cervix, testicle, brain, eye, and lining of the lung.

The DICER1 gene provides instructions for making a protein that plays a role in regulating the activity (expression) of other genes. The Dicer protein aids in the production of a molecule called microRNA (miRNA).

Sep 1, 2014 · Dicer is a type III cytoplasmic endoribonuclease that is involved in the maturation of several classes of small non-coding RNAs, such as microRNAs.