CYP8B1 is an endoplasmic reticulum membrane protein and catalyzes the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these two steroids determines the relative amounts of the two primary bile acids , cholic acid and chenodeoxycholic acid , both of which are secreted in the ...

cyp8b1是ca合成关键酶，它决定了非12-oh bas（cdca，α/β-mca，udca，lca, hca, hdca及其他替代途径的衍生物）与12-oh bas（ca，dca）的比例。 最近研究表明，cyp8b1耗竭或下调引起12-oh ba水平减少，从而增加了非-12-oh / 12-oh ba的比例，对宿主代谢状态产生有益影响。

Dec 24, 2024 · CYP8B1 (Cytochrome P450 Family 8 Subfamily B Member 1) is a Protein Coding gene. Diseases associated with CYP8B1 include Intrahepatic Cholestasis Of Pregnancy and Extrahepatic Cholestasis. Among its related pathways are Oxidation by cytochrome P450 and Bile acid and bile salt metabolism.

甾醇12α-羟化酶（cyp8b1）是一种必需酶，用于合成胆酸和调节肝胆酸的合成以及肠内胆固醇的吸收。本研究评估了固醇调节元件结合蛋白（srebps）在cyp8b1基因调节中的作用。与胆固醇7α-羟化酶（cyp7a1）的上调相反，小鼠和大鼠的胆固醇喂养降低了cyp8b1的活性。

Feb 19, 2025 · Title: Human sterol 12a-hydroxylase (CYP8B1) is mainly expressed in hepatocytes in a homogenous pattern. Isoflavone-related induction of 12-alpha-hydroxylase (CYP8B1) was studied in vitro and murine in vivo models.

Sep 1, 2022 · Cytochrome P450 8B1 (CYP8B1), which synthesizes CA, was induced in livers of colitic mice. CA-treated or liver Cyp8b1-overexpressing mice developed more severe colitis with compromised repair of the mucosal barrier, whereas Cyp8b1-knockout mice were resistant to …

Sep 1, 2022 · CA-treated or liver Cyp8b1-overexpressing mice developed more severe colitis with compromised repair of the mucosal barrier, whereas Cyp8b1-knockout mice were resistant to colitis. Mechanistically, CA inhibited peroxisome proliferator-activated receptor alpha (PPARα), resulting in impeded fatty acid oxidation (FAO) and impaired Lgr5 ...

Sep 6, 2022 · 研究通过肠特异性敲除Pparα的结肠炎小鼠证实了CYP8B1-CA代谢轴通过抑制PPARα介导的FAO，削弱Lgr5 + ISC的更新能力，加重肠道屏障损伤。 研究应用FXR激动剂奥贝胆酸（OCA）间接抑制结肠炎小鼠体内CYP8B1的活性，可促进其Lgr5 + ISC的增殖和传代能力，验证了肝脏FXR-CYP8B1 ...

Sep 4, 2022 · 进一步采用特异性敲除肠Ppara的小鼠，研究人员证实了CYP8B1-CA代谢轴通过抑制PPARα介导的FAO过程，阻碍Lgr5+ISCs的更新，加重IBD状态下的肠道屏障损伤。 图一.

关于 cyp8b1 Cytogenetic location: 3p22.1 Genomic coordinates (GRCh38): 3:42,872,192-42,875,879 (from NCBI) This gene has 2 transcripts (splice variants), 254 orthologues and 1 paralogue.