Nov 6, 2023 · The meaning of CYCLASE is an enzyme (such as adenylate cyclase) that catalyzes cyclization of a compound.

Type V adenylyl cyclase is highly enriched in brain and is localized largely to the striatum and related structures, such as the nucleus accumbens and olfactory tubercle, which are …

Class III adenylate cyclases are signaling proteins present in bacteria, archaea, and eukaryotes. Domain architectures of bacterial adenylate cyclases include modules from various signaling …

Aug 7, 2020 · Here, we report that the catalytic activity of the terpene cyclases AaTPS and FgGS can be switched from cyclase to aromatic prenyltransferase at basic pH to generate …

Aug 1, 2020 · Adenylyl cyclases (ACs) are the enzymes that generate cAMP, and thus the key components of the cAMP signaling and regulation pathways. In this review we provide a brief …

Aug 25, 2017 · Terpenoid cyclases catalyze the most complex chemical reactions in biology, in that more than half of the substrate carbon atoms undergo changes in bonding and …

Jan 23, 2023 · Here we report that PloI4, a β-barrel-fold protein homologous to the exo -selective 4 + 2 cyclase that functions in the biosynthesis of pyrroindomycins, catalyses competitive 2 + 2 …

Feb 24, 2025 · BACKGROUND: Pharmacological treatments for fibrocalcific aortic valve stenosis (FCAVS) have been elusive for >50 years. Here, we tested the hypothesis that reactivation …

Sep 11, 2024 · Here the authors identify key molecular interactions that guide lasso peptide folding and cyclase substrate tolerance to inform cyclase engineering for expanded lasso …

Sep 13, 2017 · Here, I review key advances in terpenoid cyclase structural and chemical biology, focusing mainly on terpenoid cyclases and related prenyltransferases for which X-ray crystal …