2024年12月24日 · CNOT7 (CCR4-NOT Transcription Complex Subunit 7) is a Protein Coding gene. Among its related pathways are Gene expression (Transcription) and Deadenylation-dependent mRNA decay. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is CNOT8.

CCR4-NOT transcription complex subunit 7 is a protein that in humans is encoded by the CNOT7 gene. [5][6][7][8] It is a subunit of the CCR4-Not deadenylase complex. The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation.

2025年2月8日 · CNOT7 modulates biological functions of ovarian cancer cells via AKT signaling pathway. Data show that incorporation of ATP-dependent RNA helicase eIF4A-2 (eIF4A2) into the CCR4-NOT complex inhibits CCR4-NOT transcription complex subunit 7 …

To examine whether CNOT7/8 catalytic activity is critically involved in MEF viability, we introduced either FLAG epitope-tagged CNOT7-WT or CNOT7 mutants into Cnot7/8-dKO MEFs, using a recombinant retrovirus.

2020年5月20日 · CNOT7 depletion reverses natural killer cell resistance by modulating the tumor immune microenvironment of hepatocellular carcinoma. Ren C, Ren X, Cao D, Zhao H, Zhai Z, Li H, Li Y, Fu X, He J, Zhao HRen C, et al. FEBS Open Bio, 2020 May. PMID 32160402. CNOT7 regulates lipid deposition in nonalcoholic fatty liver disease.

2017年7月18日 · In mice, CNOT7 is essential for hippocampal-dependent learning and memory. This study identifies CNOT7 as an important regulator of RNA transport and translation in dendrites, as well as higher cognitive function.

2022年5月15日 · Depletion of CNOT7 increased CNOT8 incorporation into the CCR4-NOT complex and stabilized CNOT8. These data suggest that CNOT7 is the dominant paralog in CCR4-NOT and that CNOT7 and CNOT8 protein stability is regulated in distinct ways.

2021年3月1日 · Aims: CNOT7 plays an important role in many biological processes, providing attractive opportunities for the treatment of malignant tumors. However, the functions and mechanism of CNOT7 in ovarian cancer (OC) have not been elucidated. The purpose of this study was to assess the role of CNOT7 in OC.

CNOT7 is a prognostic marker in Bladder urothelial carcinoma, Colon adenocarcinoma, Kidney renal clear cell carcinoma, Liver hepatocellular carcinoma

2017年8月8日 · In human cells, alternative splicing of the C NOT7 gene yields a second CNOT7 transcript leading to the formation of a shorter protein, CNOT7 variant 2 (CNOT7v2). Biochemical characterization indicates that CNOT7v2 interacts with CCR4–NOT subunits, although it does not bind to BTG proteins.