Chemokine like receptor 1 also known as ChemR23 (Chemerin Receptor 23) is a protein that in humans is encoded by the CMKLR1 gene.

2024年12月24日 · CMKLR1 (Chemerin Chemokine-Like Receptor 1) is a Protein Coding gene. Diseases associated with CMKLR1 include Monckeberg Arteriosclerosis and Cardiovascular Syphilis. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.

CMKLR1 is expressed by circulating pDC in normal individuals and patients suffering from skin diseases, such as psoriasis and atopic dermatitis. Observational study of gene-disease association. (HuGE Navigator)

Chemokine-like receptor 1 (CMKLR1), also known as ChemR23, and chemokine (C-C motif) receptor-like 2 (CCRL2) are 7-transmembrane receptors that were cloned in the late 1990’s based on their homology to known G-protein-coupled receptors.

CMKLR1 is a new addition to the repertoire of cell surface molecules that are responsible for Aβ processing and clearance. Keywords: Alzheimer's disease; amyloid-β; chemerin receptor; chemotaxis; microglial cells. Amyloid-β peptides such as Aβ1-42 (Aβ42) play a pivotal role in the progression of Alzheimer's disease (AD).

2024年6月19日 · By analyzing single-cell RNA sequencing datasets, we demonstrated CMKLR1 expression as a transient signature of monocyte-derived macrophages (MDMφ) enriched in patients with idiopathic pulmonary fibrosis (IPF).

Chemerin receptor (CMKLR1) is a G protein-coupled receptor (GPCR) implicated in macrophage-mediated inflammation and in several forms of human arthritis. Analogous to other GPCR, CMKLR1 is likely regulated by G protein-coupled receptor kinase (GRK) phosphorylation of intracellular domains in an acti …

2023年2月1日 · Our results reveal that CMKLR1 deficiency impedes macrophage phenotypic transformation and cardiac repair after MI involving the PI3K/AKT/mTOR pathway. CMKLR1 may thus represent a potential therapeutic target for MI.

2021年4月23日 · Enables adipokinetic hormone binding activity and adipokinetic hormone receptor activity. Involved in several processes, including negative regulation of NF-kappaB transcription factor activity; positive regulation of macrophage chemotaxis; and regulation of calcium-mediated signaling.

2024年3月26日 · CMKLR1 signaling specifically inhibits IL-33 expression induced by cell wall components but not secreted proteins of S. aureus by inhibiting Akt activation in mouse keratinocytes.