In organic chemistry, the Claisen–Schmidt condensation is the reaction between an aldehyde or ketone having an α-hydrogen with an aromatic carbonyl compound lacking an α-hydrogen. It can be considered as a specific variation of the aldol condensation.

2023年1月15日 · write a detailed mechanism for a Claisen condensation reaction or its reverse. identify the product formed in a given Claisen condensation reaction. identify the ester and other reagents needed to form a given β ‑keto ester by a Claisen condensation reaction.

2024年5月2日 · The Claisen-Schmidt condensation is a reaction that was first reported by Claisen (University of Bonn) and Schmidt (ETH Zurich) in 1881. It involves the condensation of an aromatic aldehyde with an aliphatic aldehyde or ketone in the presence of a base or an acid to form an α,β-unsaturated aldehyde or ketone with high chemoselectivity.

The Claisen-Schmidt condensation reaction is an organic reaction in which a ketone or an aldehyde holding an α-hydrogen reacts with an aromatic carbonyl compound which does not have any α-hydrogens. This reaction is named after the chemists J.G. Schmidt and …

2022年4月14日 · The reaction between an aldehyde or ketone having an α-hydrogen with an aromatic carbonyl compound lacking an α-hydrogen is called the Claisen–Schmidt condensation. This reaction is named after two of its pioneering investigators Rainer Ludwig Claisen and J. G. Schmidt, who independently published on this topic in 1880 and 1881.

2023年1月23日 · The reaction between an aldehyde/ketone and an aromatic carbonyl compound lacking an alpha-hydrogen (cross aldol condensation) is called the Claisen-Schmidt condensation. This reaction is named after two of its pioneering investigators Rainer Ludwig Claisen and J. G. Schmidt, who independently published on this topic in 1880 and 1881.

2020年9月14日 · In this post we’ll show each step of the Claisen condensation mechanism in detail, along with examples of crossed Claisen condensations and Dieckmann condensations. There are quiz questions at the end that will test you on some of the key concepts.

2022年1月23日 · Claisen-Schmidt condensation involves the nucleophilic attack of carbanion on an electron-deficient carbonyl carbon atom followed by loss of an anion.

Since ketones are less reactive toward nucleophilic addition, the enolate formed from a ketone can be used to react with an aldehyde, a modification called the Claisen-Schmidt reaction.

The Claisen-Schmidt condensation is a specific type of crossed aldol reaction involving an enolizable aldehyde and an enolizable ketone. Unlike typical crossed aldol reactions, where one carbonyl compound is non-enolizable, both reactants in this reaction can form enolates.