2024年12月24日 · CKAP4 (Cytoskeleton Associated Protein 4) is a Protein Coding gene. Diseases associated with CKAP4 include Cystitis and Interstitial Cystitis.Among its related pathways are Signaling by Rho GTPases and Innate Immune System.Gene Ontology (GO) annotations related to this gene include RNA binding and obsolete signal transducer activity.An important paralog of this gene is SMC1B.

Cytoskeleton-associated protein 4 is a protein that in humans is encoded by the CKAP4 gene. [5] [6]CKAP4 also historically known as CLIMP-63 (cytoskeleton-linking membrane protein 63), or just p63 (during the 1990s) is an abundant type II transmembrane protein residing predominantly in the endoplasmic reticulum (ER) of eukaryotic cells …

细胞骨架相关蛋白4的生物学功能及其在慢性肾脏病血管钙化中作用的研究进展. 史玉萍, 袁伟杰, 戎殳

2023年3月21日 · Cytoskeleton-associated protein 4 (CKAP4) is a non-glycosylated type II transmembrane protein that serves as a cell surface-activated receptor. It is expressed primarily in the plasma membranes of bladder epithelial cells, type II alveolar pneumocytes, and vascular smooth muscle cells. CKAP4 is involved in various biological activities including cell proliferation, cell migration, keratinocyte ...

HA-tagged CKAP4 was inserted into lentivirus vectors as described previously . pLVSIN-EF1α Neo/CKAP-HA was used as a template to construct vectors pLVSIN-EF1α Neo/CKAP-HA (Δ2-21) and pLVSIN-EF1α Neo/CKAP-HA (Δ24-101). pLVSIN-EF1α Neo/CKAP-HA (Δ2-21) and pLVSIN-EF1α Neo/CKAP-HA (Δ24-101) were amplified with the KOD-FX mutagenesis kit ...

2021年2月4日 · The intracellular region contains a proline-rich region (AA 36–59) followed by seven glycine, six serine, and eight alanine repeats. Mutational analysis demonstrated that the cytoplasmic domain of CKAP4 carries two functionally distinct determinants: ER-anchoring domain (AA 2–21) and a microtubule binding domain (AA 24–101) (Schweizer et al., 1994) ().

Dickkopf1 (DKK1) is a secretory protein that antagonizes oncogenic Wnt signaling by binding to the Wnt coreceptor low-density lipoprotein receptor–related protein 6 (LRP6). DKK1 may also regulate its own signaling to promote cancer cell ...

Cytoskeleton-associated protein 4 (CKAP4) is a non-glycosylated type II transmembrane protein that serves as a cell surface-activated receptor. It is expressed primarily in the plasma membranes of bladder epithelial cells, type II alveolar pneumocytes, and vascular smooth muscle cells. CKAP4 is invo …

In addition, CKAP4 serum levels in mice transplanted with NCI-H292/CKAP-HA cells were decreased upon anti-CKAP4 antibody administration. Taken together with A549 cell data , these results support that CKAP4 is an appropriate molecular target of lung cancer cells expressing DKK1 and CKAP4.

2022年1月6日 · In this article, Rossi et al. provide an interesting mechanism in which circZNF609-mRNA interaction increases translation, and among them, CKAP5 is a key factor in microtubule dynamics stability. The authors show how the disruption of RNA-RNA interactions is able to alter microtubule dynamics, sensitizing rhabdomyosarcoma cells to chemotherapeutic drugs.