CHK2 kinase in the DNA damage response and beyond - PMC
The serine/threonine kinase CHK2 is a key component of the DNA damage response. In human cells, following genotoxic stress, CHK2 is activated and phosphorylates >20 proteins to induce …
CHEK2 Gene - GeneCards | CHK2 Protein | CHK2 Antibody
Dec 24, 2024 · CHEK2 (Checkpoint Kinase 2) is a Protein Coding gene. Diseases associated with CHEK2 include Tumor Predisposition Syndrome 4 and Prostate Cancer. Among its related …
The Chk2 protein kinase - PubMed
Checkpoint kinase 2 (Chk2) is a multifunctional enzyme whose functions are central to the induction of cell cycle arrest and apoptosis by DNA damage. Insight into Chk2 has derived …
The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling …
In addition, suppressing DNA damage and replication checkpoint responses by inhibiting Chk1 can enhance tumor cell killing by diverse genotoxic agents. Here, we review current …
CHK2 DNA损伤检查点激酶的结构和激活机制,Molecular Cell - X …
CHK2蛋白激酶是DNA损伤检查点信号的重要转导者，其突变有助于遗传和散发性癌症。 DNA损伤激活的ATM激酶使Thr68磷酸化，从而触发CHK2激活。 这导致瞬时的CHK2二聚化，部分地 …
CHK2 kinase: cancer susceptibility and cancer therapy - Nature
CHK2 is a versatile and multifunctional kinase that regulates the cell's response to DNA damage by phosphorylating a number of distinct cellular substrates. CHK2 can prevent tumour …
Structure and Activation Mechanism of the CHK2 DNA Damage …
Sep 24, 2009 · The CHK2 protein kinase is an important transducer of DNA damage checkpoint signals, and its mutation contributes to hereditary and sporadic cancer. CHK2 activation is …
Chk2 kinase — a busy messenger - Nature Reviews Molecular Cell …
Dec 1, 2001 · Checkpoint kinase 2 (Chk2) is emerging as a key mediator of diverse cellular responses to genotoxic stress, guarding the integrity of the genome throughout eukaryotic...
细胞周期检测点激酶与肺癌耐药研究进展 - PMC
Chk2已被证实是一种肿瘤抑制因子，并且在一些癌症中发生突变或减少，包括乳腺癌、结肠癌、膀胱癌、卵巢癌和前列腺癌。Chk2的低表达或缺失对肿瘤有保护作用，可能与肿瘤的发生发展 …
Chk2蛋白激酶生物学功能研究进展 - 百度文库
Checkpoint kinase 2 (Chk2，又被称作hCds1或Chek2)是一种多功能蛋白激酶，作为肿瘤抑制基因，在多种肿瘤中发现其发生突变，包括肝癌、乳腺癌、卵巢癌、膀胱癌、前列腺癌和结肠癌 …