CFU-GEMM is a colony forming unit that generates myeloid cells. CFU-GEMM cells are the oligopotential progenitor cells [1][2] for myeloid cells; they are thus also called common myeloid progenitor cells or myeloid stem cells. "GEMM" stands for granulocyte, erythrocyte, monocyte, megakaryocyte. [3]

Aug 10, 2012 · 近日来自四川大学、加州大学等处的研究人员发表了题为“Complement factor H genotype impact risk of age-related macular degeneration by interaction with oxidized phospholipids”的研究论文，揭示了补体因子H(CFH)基因型影响年龄相关性黄斑变性（AMD）的风险的分子作用机制。

补体因子H(complement factor H，CFH)是补体激活调节蛋白(regulator of complement activation，RCA)基因簇的重要成员之一，CFH基因定位于染色体1q31.3，全长95.4kb，包含25个外显子，编码1 231个氨基酸，是一种由20个短同源重复序列(short consensus repeats，SCRs)，又叫补体调控蛋白 ...

Deficiency of and mutations in the complement factor H (CFH) gene are associated with the development of MPGN II/DDD, suggesting that dysregulation of the alternative pathway of the complement cascade is important in disease pathophysiology.

Jan 2, 2025 · Complement factor H macular degeneration, also known as CFH macular degeneration, is a genetic eye disorder that affects the macula, the central part of the retina. It is caused by mutations in the complement factor H (CFH) gene, which plays a role in regulating the immune system and inflammation in the body.

CFH acts as a cofactor for Complement Factor I (CFI) to irreversibly inactivate C3b to iC3b, thereby regulating C3bBb activity as well as enabling opsonin mediated debris clearance mechanisms. Additionally, CFH binds to mammalian cell surfaces to protect self-cells from complement activation.

Aug 8, 2023 · Complement factor H (CFH) negatively regulates consumption of complement component 3 (C3), thereby restricting complement activation. Genetic variants in CFH predispose to chronic inflammatory disease. Here, we examined the impact of …

Jun 22, 2017 · Here we describe a comprehensive procedure to measure levels and functional activity of complement regulator factor H (FH) encoded by CFH, the commonest genetic factor associated with aHUS and C3G, and present the results of the analysis of 28 uncharacterized, disease-associated, FH variants.

补体因子H（CFH）基因家族的结构变异和单核苷酸变异是几种复杂的遗传疾病的基础，包括年龄相关性黄斑变性（AMD）和非典型溶血性尿毒症综合征（AHUS）。为了了解其多样性和进化，我们在六个灵长类谱系（包括多种人类单倍型）中对该〜360 kbp基因座进行了高 ...

Complement factor H (CFH), originally known as beta-1H globulin, is a serum glycoprotein that regulates the function of the alternative complement pathway in fluid phase and on cellular surfaces.