CD93 (also known as complement protein 1 q subcomponent receptor C1qR1 or C1qRp), is a transmembrane glycoprotein encoded by a gene located on 20p11.21 and composed of 652 amino acids. CD93 can be present in two forms: soluble (sCD93) and membrane-bound (CD93).

2024年12月24日 · CD93 (CD93 Molecule) is a Protein Coding gene. Diseases associated with CD93 include Atypical Hemolytic-Uremic Syndrome and Immune Deficiency Disease. Among its related pathways are Innate Immune System and Immune response Lectin …

2023年7月4日 · CD93 can be present in two forms: soluble (sCD93) and membrane-bound (CD93). CD93 is mainly expressed on endothelial cells, where it plays a key role in promoting angiogenesis both in physiology and disease, such as age-related macular degeneration and tumor angiogenesis.

Cluster of Differentiation (CD) 93 (also known as complement protein 1 q subcomponent receptor C1qR1 or C1qRp) is a transmembrane glycoprotein that can also be present in a soluble (sCD93) form. Recent studies have investigated the role of this protein in cardiovascular disease (CVD).

CD93 regulates phagocytosis of apoptotic cells in vivo, a function critical to development, tissue repair and maintenance of tissue homeostasis. In addition, in vitro studies have demonstrated a role for CD93 in phagocytosis of antibody and complement opsonized particles and also in leukocyte and endothelial cell adhesion.

The CD93/IGFBP7 axis proteins are key factors expressed in endothelial cells (EC) that mediate EC angiogenesis and migration. Their upregulation contributes to tumor vascular abnormality and a blockade of this interaction promotes a favorable tumor microenvironment for …

Following a comprehensive review of CD93 expression patterns, this review will focus on recent findings over the last three years that address the putative function of CD93 in inflammation and innate immunity.

2025年2月8日 · CD93 regulates breast cancer growth and vasculogenic mimicry through the PI3K/AKT/SP2 signaling pathway activated by integrin beta1. Structural insight into CD93 recognition by IGFBP7. Blockade of CD93 in pleural mesothelial cells fuels anti-lung tumor immune responses.

CD93, or C1q-Rp, is a 120-kDa O-sialoglycoprotein, the equivalent of the AA4 antigen in mice, and is classed as a defense collagen receptor for C1q. CD93 is a member of the C-type lectin family and the N-terminal domain has this fold.

CD93 regulates breast cancer growth and vasculogenic mimicry through the PI3K/AKT/SP2 signaling pathway activated by integrin beta1. Structural insight into CD93 recognition by IGFBP7. Blockade of CD93 in pleural mesothelial cells fuels anti-lung tumor immune responses.