CD7 (Cluster of Differentiation 7) is a protein that in humans is encoded by the CD7 gene. [5]

2024年12月24日 · CD7 (CD7 Molecule) is a Protein Coding gene. Diseases associated with CD7 include Mycosis Fungoides and Lymphoblastic Lymphoma . Among its related pathways is Innate Lymphoid Cells Differentiation .

2003年3月1日 · CD7 identifies three populations of CD8 T cells: CD7 high (CD7(high)), low (CD7(low)), and negative (CD7(neg)) that translate into subsets with distinct functional properties. The CD7(high) subset contains naive and memory cells and the CD7(low) and CD7(neg) subsets contain effector cells.

CD7 is a single-domain Ig superfamily molecule expressed on human T and NK cells, as well as on cells in the early stages of T, B, and myeloid cell differentiation. CD7 is highly expressed on malignant immature T cells and is generally absent on malignant mature T cells, such as CD4+ Sezary leukemia …

The CD7 transmembrane protein is expressed by T cells, NK cells and their precursors. It is present in >95% of lymphoblastic T-cell leukemias and lymphomas and a subset of PTCLs [24,45]. It has costimulatory role in T-cell activation. However, unlike the CD5 CAR construct, which lost CD5 [23], CD7 persists causing

CD7, also known as GP40, is a membrane-expressed protein that belongs to the immunoglobulin superfamily. CD7 expression was detected in T cells and subsequently shown to also be present on natural killer (NK) cells [, , ], indicating a role for CD7 in the immune system.

2024年6月19日 · CD7, also known as GP40, is a 40 kDa glycoprotein encoded by the CD7 gene located on chromosome 17. It belongs to the immunoglobulin superfamily and contains a single extracellular immunoglobulin-like domain, a transmembrane region, and a short cytoplasmic tail.

2025年2月8日 · CD7 antigen notably expresses in lung microvascular endothelial cells (LME) and that it acts as an Fc receptor for IgM in LME cells. a novel fusion protein, designated scFvCD7:sFasL is designed to have leukemia-restricted activity.

2024年12月10日 · Title: CD7 activation regulates cytotoxicity-driven pathology in systemic sclerosis, yielding a target for selective cell depletion. Base-Edited CAR7 T Cells for Relapsed T-Cell Acute Lymphoblastic Leukemia.

Interestingly, under physiological and different pathological conditions, the loss of CD7 antigen occurred in the subset of CD4 + memory T cells. Various functions have been proposed for CD7, including its role in the activation and intercellular adhesiveness of T cells.