2024年12月24日 · CD63 (CD63 Molecule) is a Protein Coding gene. Diseases associated with CD63 include Fundus Albipunctatus and Congenital Stationary Night Blindness. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. An important paralog of this gene is TSPAN3.

The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression.

CD63 is a ubiquitously expressed protein that is localized within the endosomal system and at the cell surface (Fig. 1). In most cells the major pool of CD63 resides in late endosomes/MVBs and lysosomes, which is why it is also referred to as a lysosomal membrane protein.

2024年6月21日 · CD63 is a marker protein of exosomes, with exosomes containing CD63 underpinning tumor cells’ ability to communicate with surrounding cells, for example, other tumor cells, immune cells,...

2009年5月15日 · CD63 was the first characterized tetraspanin. In addition to its presence in TEMs, CD63 is also abundantly present in late endosomes and lysosomes.

2025年1月4日 · Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins.

2025年2月8日 · The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this …

2017年4月15日 · Protein target information for CD63 antigen (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

2024年11月3日 · The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this …

Here, we reviewed the characteristics and functions of TIMP-1 and its binding partners, CD63 and β1-integrin, and the evidence indicating that the pleiotropic functions of TIMP-1 could be regulated by the presence of aberrant N- glycosylation patterns. 2. Characteristics and Structure of TIMP-1.