In particular, the CD2-CD58 interaction is involved in the regulation of antiviral responses, inflammatory responses in autoimmune diseases, immune rejection of transplantation, and immune evasion of tumor cells. In this review, we provide a …

2024年12月24日 · CD58 (CD58 Molecule) is a Protein Coding gene. Diseases associated with CD58 include Hematologic Cancer and Paroxysmal Nocturnal Hemoglobinuria . Among its related pathways are Innate Immune System and Response to elevated platelet cytosolic Ca2+ .

2021年6月8日 · The glycoprotein CD58, also known as lymphocyte-function antigen 3 (LFA-3), is a costimulatory receptor distributed on a broad range of human tissue cells. Its natural ligand CD2 is primarily expressed on the surface of T/NK cells.

2022年5月19日 · A preprint by Ho et al. investigates the role of decreased CD58 expression in cancer cell immune evasion, through both lack of T cell co-stimulation and increased T cell inhibition.

2023年6月15日 · We show that intact cancer cell CD58 expression is required for effective T cell-mediated anti-tumor responses, and that loss of CD58 confers cancer immune evasion through multiple mechanisms, including impaired activation and proliferation of T cells; reduced tumor lytic capacity, tumor infiltration, and intratumoral T cell expansion; and inter...

2022年11月22日 · We found that disruption of CD58 in tumor cells induced the formation of suboptimal immunological synapse (IS) with CAR T cells, which conferred functional impairment of CAR T cells, including the attenuation of cell expansion, degranulation, cytokine secretion, and …

2023年11月2日 · Thus, the aim of this study was to comprehensively characterize CD58 genetic alterations in DLBCL, unveil the multiple roles of CD58 in anti-tumor immunity, and provide insights for potential therapeutic strategies.

2022年11月22日 · We found that disruption of CD58 in tumor cells induced the formation of suboptimal immunological synapse (IS) with CAR T cells, which conferred functional impairment of CAR T cells, including the attenuation of cell expansion, degranulation, cytokine secretion, and …

2025年2月8日 · Results indicate that CD58 is a novel cell-surface marker that functionally regulates self-renewal of Colorectal tumor-initiating cells. The positive correlation is established between content of polymorphic nuclear monocytes and level of expression of molecules of LFA-1, ICAM-1, LFA-3, and PECAM-1.

Our results confirm and further evidence the role of CD58 in the diagnosis and monitoring of precursor-B ALL. In particular, we demonstrated its stability and accuracy in MRD detection at clinically relevant time points.