In immunohistochemistry, CD31 is used primarily to demonstrate the presence of endothelial cells in histological tissue sections. This can help to evaluate the degree of tumor angiogenesis, which can imply a rapidly growing tumor.

2013年6月1日 · Although it is expressed by all leukocytes, including T-, B-lymphocytes and dendritic cells, the immunoglobulin-like receptor CD31 is generally regarded by immunologists as a marker of endothelial cell lineage that lacks an established functional role in adaptive immunity.

2012年2月29日 · CD31 is a 130 kDa platelet–endothelial cell (EC) adhesion molecule that was initially identified from ECs and platelets 1 and later from blood leucocytes. 2 Mature CD31 contains a short [22-amino acid (aa)] NH 2-terminal peptide followed by six C2-type immunoglobulin (Ig) domains, each flanked by two conserved cysteine residues outside the ...

2017年3月15日 · CD31, also known as PECAM-1, is a single-chain 130-kDa glycoprotein consisting of six Ig-like extracellular domains, a short transmembrane segment, and a cytoplasmic tail containing two immunoreceptor tyrosine-based inhibitory motifs (ITIMs).

CD31 or Platelet/endothelial cell adhesion molecule-1 (PECAM-1) is a 130-kDa cell adhesion molecule that is highly expressed on the surface of endothelial cells and to a lesser extent on a range of hematopoietic cells, such as platelets, monocytes, neutrophils and T-cell subsets.

3 天之前 · These markers contribute to cell adhesion, signaling, and structural integrity. Among the most widely used are CD31, VE-cadherin, and CD34. CD31. CD31, or platelet endothelial cell adhesion molecule-1 (PECAM-1), is a transmembrane glycoprotein primarily expressed on endothelial cells and certain immune cells.

2009年1月22日 · However, recently, CD31 has been introduced as a marker to distinguish 2 subsets of naive CD4 + T cells with distinct T-cell receptor excision circle (TREC) content in the peripheral blood of healthy humans.

In this study, we provide a global picture of the evolution of CD31 expression from the CD34 (+) hematopoietic precursor to the CD45RA (+) mature CD4 (+) and CD8 (+) single-positive (SP) T cells.

CD31 (cluster of differentiation 31) is expressed on endothelial cells, showing some membrane and occasional cytoplasmic staining. It is not expressed on discontinuous endothelium (eg, splenic red pulp).

CD31 is an established biomarker for angiogenesis during vascularization. CD31 is believed to play an important role in cancer metastasis due to its ability to support dynamic multi-directional interactions with other proteins on both endothelial cells and platelets. CD31 is also involved in thrombus formation when bound with fibrinogen or TSP1.