CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils [6] and neutrophil precursors from the myelocyte stage onwards. The encoded protein is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface.

2024年12月24日 · CD24 (CD24 Molecule) is a Protein Coding gene. Diseases associated with CD24 include Erythroleukemia and Multiple Sclerosis. Among its related pathways are Nervous system development and L1CAM interactions. Gene Ontology (GO) annotations related to this gene include protein kinase binding and carbohydrate binding.

1978年，科学家首次发现CD24，即分化簇24（Cluster of differentiation 24），也称为热稳定抗原（heat-stable antigen，HSA)，一种高度糖基化的糖基磷脂酰肌醇(GPI)锚定的膜蛋白。CD24没有胞内信号结构域，然而，…

2019年8月5日 · 多种肿瘤过表达CD24，且肿瘤相关巨噬细胞上表达了高水平的Siglec-10。通过对CD24或Siglec-10进行基因消融或使用抗体阻断CD24-Siglec-10相互作用，研究中所检测的所有表达CD24的人类肿瘤中巨噬细胞的吞噬作用均显著增强。

Here we show that CD24 can be the dominant innate immune checkpoint in ovarian cancer and breast cancer, and is a promising target for cancer immunotherapy. We demonstrate a role for tumour-expressed CD24 in promoting immune evasion through its interaction with the inhibitory receptor sialic-acid-binding Ig-like lectin 10 (Siglec-10), which is ...

2010年2月15日 · Cell-surface and cytoplasmic expression of CD24 correlates to poor prognosis, histology grades, tumor sizes and lymph node positivity. 96, 97 In non-small cell lung cancer, CD24 expression is...

2023年11月2日 · Cluster of differentiation 24 (CD24), a mucin-like highly glycosylated molecule has been extensively studied as a cancer stem cell marker in a variety of solid cancers. The functional role of CD24 is either fulfilled by combining with ligands or participating in signal transduction, which mediate the initiation and progression of neoplasms.

cd24 fc是由昂科免疫公司开发的一种重组人cd24胞外域和人免疫球蛋白g1（igg1）的fc段的融合蛋白，最初适用于治疗植抗宿主病（gvhd），今年新冠疫情爆发，科学家们发现该药物可以用于治疗新型冠状病毒肺炎。

2024年9月20日 · CD24被认为是卵巢癌和乳腺癌的主要天然免疫检查点，与PD-1机理类似并互补，是癌症免疫疗法很有希望的新靶标。通过阻断CD24-Siglec-10间的相互作用，可以减缓肿瘤细胞生长，提高巨噬细胞的吞噬能力，从而延长实验对象的存活时间。

现在经过 car19治疗 后的患者白血病/淋巴瘤细胞表面cd19阴后，可用cd24设门。 cd86. cd86蛋白（分化86簇）是一种在抗原呈递细胞上表达的分子，它提供t细胞活化和生存所需的共刺激信号。它是t细胞表面两种蛋白的配体，cd28抗原和ctla-4（细胞毒性t淋巴细胞相关蛋白4