2019年4月11日 · CD22 also appears to be upregulated in AD (Friedman et al., 2018). CD22 belongs to the family of sialic acid-binding immunoglobulin-like lectins, or Siglecs, which also includes CD33. Variants in CD33 suppress Aβ phagocytosis and increase risk for Alzheimer’s disease (Griciuc et al., 2013; Aug 2013 news).

2021年12月8日 · Siglec 2, CD22, is a receptor predominantly expressed in peripheral B cells; but in brain, Wyss-Coray and colleagues identified CD22 expression to be enriched in human oligodendrocytes, and its direct binding partner IGF2R in microglia.

2022年4月26日 · Human CD22 is expressed by several cell types, including oligodendrocytes, B cells, and Sertoli cells (Poe and Tedder, 2012; Pluvinage et al., 2021; Human Protein Atlas). It is critical to clarify the source of plasma sCD22, which determines the correlations of plasma sCD22 and AD observed in our study.

2019年4月11日 · Pluvinage et al. elucidate previously unappreciated roles for CD22 in the aging brain. Comparing young and old mice, the group of Tony Wyss-Coray observed that CD22 is increased in microglia during aging. This observation was rather unexpected as CD22 is an inhibitory molecule mainly known to “dampen” the activation of B-lymphocytes.

2021年12月8日 · Significantly, a soluble form of CD22 (sCD22) was found to be elevated in a rare progressive genetic disorder, Niemann-Pick type C, motivating a search for its origins. In the course of this work, they uncovered a provocative difference between humans and mice in that CD22 was previously reported to be microglia-specific in mouse brain but is ...

2019年4月23日 · CD22 Suppresses Microglial Phagocytosis—A New Therapeutic Target? 5 Apr 2019; Protective Microglial Gene Variant Promotes Phagocytosis 22 Aug 2013; Paper Citations. Katsumata Y, Nelson PT, Estus S, Alzheimer's Disease Neuroimaging Initiative (ADNI), …

2022年8月29日 · Associations of plasma soluble CD22 levels with brain amyloid burden and cognitive decline in Alzheimer's disease. 03 May 2022; John Trojanowski, 75, a Giant in the Field of Neuropathology 15 Feb 2022

2004年6月23日 · Triple-Colour Reagent, Anti-Human TdT/FITC Anti-Human CD22/RPE Anti-Human CD3/APC; simultaneous detection and enumeration of T and B-lymphocyte precursor cells, B cells and T cells. Comments / Questions. No Available Comments. Make a comment or submit a question. To make a comment you must login or register. References. No Available …

2025年1月8日 · It never occurred to the family that both brothers could have the same rare genetic condition. In 2017, neurologists at New York Presbyterian/ Columbia University’s movement clinic diagnosed Daniel with Niemann-Pick disease Type C (NPC): a lysosomal storage disorder caused by NPC1 mutations.

2020年6月30日 · CD22 Suppresses Microglial Phagocytosis—A New Therapeutic Target? 5 Apr 2019; CD22 Suppresses Microglial Phagocytosis—A New Therapeutic Target? 5 Apr 2019; Could CD33 Be the Microglial Target for Stimulating Phagocytosis? 23 Apr 2019; Deleting CD33 Benefits Mice—If Their Microglia Express TREM2 11 Jul 2019