CD205 is an endocytic receptor that is expressed at high levels by cortical thymic epithelial cells and by dendritic cell (DC) subsets, including the splenic CD8+ DC population that is responsible for cross-presentation of apoptotic cell-derived antigens.

Our results suggest that CD205 has two distinct functions -- one as an endocytic receptor on immature dendritic cells and a second as a non-endocytic molecule on mature dendritic cells -- and further highlight its potential as an immuno-modulatory target for …

May 30, 2017 · These features make CD205 ideal to be exploited as target of a novel ADC. MEN1309/OBT076 is a humanized IgG1 antibody against CD205, conjugated through a cleavable linker to a potent maytansinoid microtubule disruptor, DM4.

Background: CD205 is a type I transmembrane surface protein belonging to the mannose receptor family with propensity for antigen uptake/internalization. CD205 is expressed in different cancer histotypes and seems to have a role in migration and invasion.

We present a detailed analysis of CD205 expression, distribution and endocytosis in human monocyte-derived dendritic cells undergoing lipopolysaccharide-induced maturation. Unlike other members of the macrophage mannose receptor family, CD205 was …

CD205, previously known as DEC-205, is a C-type lectin that belongs to the family of macrophage mannose receptors (MMR). In humans, it is highly expressed on myeloid blood dendritic cells (DC) and monocytes; at medium levels on B cells and low levels on NK cells, plasmatoid DC and T …

CD205 is a type I transmembrane glycoprotein and is a member of the C-type lectin receptor family. Analysis by mass spectrometry revealed that CD205 was robustly expressed and highly prevalent in a variety of solid malignancies from different histotypes.

We found that CD8 + CD205 + DCs were selectively active in vitro and in vivo. Therefore, CD8 + CD205 + DCs from the spleen can differentiate Foxp3 + regulatory T cells from Foxp3 − precursors in the periphery, as CD103 + DCs can induce Foxp3 in the intestinal environment.

CD205 is an endocytic receptor that is expressed at high levels by cortical thymic epithelial cells and by dendritic cell (DC) subsets, including the splenic CD8+ DC population that is responsible for cross-presentation of apoptotic cell-derived antigens.

Our CD205 monoclonal, polyclonal and recombinant monoclonal antibodies are developed in Rat, Mouse and Rabbit. Find the CD205 antibody that fits your needs. Choose from 1 of 41 CD205 antibodies, which have been validated in experiments with 38 publications and 76 images featured in our data gallery.