In molecular biology, CD18 (Integrin beta chain-2) is an integrin beta chain protein that is encoded by the ITGB2 gene in humans. [5] Upon binding with one of a number of alpha chains, CD18 is capable of forming multiple heterodimers , which play significant roles in cellular adhesion and cell surface signaling, as well as important roles in ...

Neutrophil numbers must be tightly controlled to maintain host protection and prevent neutrophil-mediated tissue injury. CD18 deficiency leads to neutrophilia and myeloid hyperplasia in the bone marrow (BM). These studies examined the role of CD18 ...

2010年2月8日 · These studies examined the function of CD18 in regulating neutrophil production and determined whether the defects in neutrophil production that are observed in CD18 deficiency persist in the...

2021年11月7日 · CD11d/CD18 is the most recently discovered and least understood β2 integrin. Known CD11d adhesive mechanisms contribute to both extravasation and mesenchymal...

CD18 is a 95 kDa glycoprotein that is a subunit of LFA-1. It consists of extracellular, transmembrane, and cytoplasmic domains, with potential glycosylation sites and cysteines for structural stability.

CD18 forms the β 2-chain of CD11a, CD11b, and CD11c (leukocyte adhesion molecule). CD18 is the major component of lymphocyte function–associated antigen 1 (LFA-1), macrophage antigen 1 (Mac-1), and CD4 integrins, which bind leukocytes to the capillary endothelium.

C CD11b/CD18. CD11b/ CD18 is a member of the leukocyte integrin family of heterodimeric adhesion molecules, which consist of a common β-subunit and a unique α-subunit. Wright and Jong (1986) first demonstrated that the integrins were capable of …

The CD11/CD18 integrins are differentiated antigens which play a critical role in this mechanism. CD11a/CD18 are apparent on early progenitors of all myeloid and erythroid cells. CD11b/CD18 and CD11c/CD18 are more restricted antigens normally expressed on monocytes, macrophages, PMN and natural killer cells.

CD11d/CD18 is the most recently discovered and least understood β2 integrin. Known CD11d adhesive mechanisms contribute to both extravasation and mesenchymal migration - two key aspects for localizing peripheral leukocytes to sites of inflammation.

CD18 is a subunit of the β2 integrin family and a leukocyte adhesion molecule that plays a crucial role in immune function. It is unique among integrins for its structure and function and is associated with the genetic defect that causes leukocyte adhesion deficiency (LAD).