CD16 expression enables antibody-mediated degranulation and thus allows T cell receptor-independent cytotoxicity. In patients with severe COVID-19, CD16-positive T cells may lead to exacerbated cytotoxicity, promote microvascular endothelial …

May 2, 2013 · Key Points. Activated NK cells loose CD16 (FcRγIII) and CD62L through a metalloprotease called ADAM17.Inhibition of ADAM17 enhances CD16 mediated NK cell f

CD16, also known as FcγRIII, is crucial in both innate and adaptive immunity. There are two isoforms: CD16A on NK cells, macrophages, and neutrophils, and CD16B mainly on neutrophils. Functions include Antibody-Dependent Cellular Cytotoxicity (ADCC), phagocytosis, and inflammation regulation.

Dec 2, 2016 · We have defined the CD14-CD16 + DC using a broad panel of cell surface markers and established a CD14-CD16 + DC phenotypic signature that is distinct from both classical and non-classical monocytes in healthy donor blood.

Jun 2, 2022 · Ravetch JV, Perussia B. Alternative Membrane Forms of Fc Gamma RIII(CD16) on Human Natural Killer Cells and Neutrophils. Cell Type-Specific Expression of Two Genes That Differ in Single Nucleotide Substitutions.

Sep 24, 2012 · The Fc receptor on NK cells, FcγRIIIA (CD16), has been extensively studied for its role in mediating antibody-dependent cellular cytotoxicity (ADCC). A homozygous missense mutation in CD16 (encoding a L66H substitution) is associated with severe herpesvirus infections in rare patients.

May 20, 2021 · Natural killer (NK) cells hold a pivotal role in tumor-targeting monoclonal antibody (mAb)-based activity due to the expression of CD16, the low-affinity receptor for IgG.

Oct 18, 2012 · Optimal effects of CD16 + monocytes on Treg and Th proliferative require direct contact with T cells and release of soluble factors. Autologous CD3 + T cells, CD14 hi CD16 − and CD16 + monocyte subsets, from ITP patients were purified from PBMCs by cell sorting.

Dec 1, 2001 · Here, we investigated the ability of CD16 + monocytes cultured with granulocyte– macrophage colony-stimulating factor, IL-4 and tumor necrosis factor-α to generate DC in vitro, and we compared them to DC derived from regular CD16 − monocytes. Both monocyte subsets gave rise to cells with DC characteristics.

The marker "CD16+ or CD56+/ CD3+" refers to a subset of immune cells that express CD16 or CD56 surface proteins along with CD3. These markers are typically associated with a specific type of T cell known as NKT (Natural Killer T) cells.