Mar 19, 2024 · Hodgkin lymphoma: membranous, diffuse cytoplasmic or Golgi staining of Reed-Sternberg cells; CD15 staining is used to confirm diagnosis, or to differentiate Hodgkin lymphoma (CD15+) from anaplastic large cell lymphoma (usually CD15-)

Oct 19, 2008 · The glycan determinant CD15 (also known as Lewis x, or Lex) is a distinguishing marker for human myeloid cells and mediates neutrophil adhesion to dendritic cells.

CD15, the X hapten or Lewis X antigen, can be identified with the LeuM1 antibody. Originally noted as a monocyte/myeloid cell marker, it was recognized as a marker for the Reed-Sternberg cells of classical Hodgkin lymphoma.

The glycan determinant CD15 (also known as Lewis x, or Le(x)) is a distinguishing marker for human myeloid cells and mediates neutrophil adhesion to dendritic cells. Despite broad interest in this structure, the mechanisms underlying CD15 expression remain relatively uncharacterized.

CD15 (3-fucosyl-N-acetyl-lactosamine) is a cluster of differentiation antigen – an immunologically significant molecule. CD15 is a carbohydrate adhesion molecule (1) that can be expressed on glycoproteins, glycolipids and proteoglycans.

Apr 28, 2022 · CD15 (Lewis X/Lex) is a fucosyl (3-fucosly-N-acetyl-lactosamine) moiety found on membrane proteins of various cancer cells. These cancers include renal cancer, prostate and bladder cancers, acute leukaemias, hepatocellular carcinoma, breast cancer and melanoma.

Apr 29, 2024 · CD15, also known as LeuM1, is a carbohydrate antigen and anti-CD15 is primarily used in the differential identification of Reed-Sternberg cells and or Hodgkin cells for classic Hodgkin lymphoma (usually positive) and the LP/L&H cells (usually negative) of Nodular lymphocyte predominant Hodgkin lymphoma.

We used flow cytometry to examine the variability of CD15 expression in normal cells and acute myeloid leukemia (AML) cells as detected by 24 murine monoclonal antibodies (mAb). Important differences in the levels of binding were observed with the various mAb.

CD15 is a haemopoietic differentiation antigen expressed on most terminally differentiated myeloid cells including granulocytes, eosinophils, mast cells, monocytes/macrophages, and Langerhans’ cells.

In this study, we examined which α1,3FUT is responsible for the CD15 expression, in conjunction with the expression of CDw65, in human leukocytes and demonstrated that the expression of CD15 is determined differentially either by FUT9 or FUT4, depending on …